{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:37:21Z","timestamp":1787600241980,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Microplastics are emerging as environmental pollutants with potential neurotoxic effects, yet their association with neurological disabilities remains largely unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study comprising 218 coastal counties in the United States, we compared the self\u2010reported prevalence of cognitive disability, mobility disability, self\u2010care disability, and independent living disability in counties with very high and low marine microplastic levels (MMLs). Unadjusted and adjusted prevalence ratios (PRs) were computed using population\u2010weighted quasi\u2010Poisson regression across three different models to examine the relationship between disability prevalence and MMLs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Counties exposed to very high marine microplastic levels had a higher mean prevalence of self\u2010reported cognitive disability (15.2% vs. 13.9%), mobility disability (14.1% vs. 12.3%), self\u2010care disability (4.2% vs. 3.6%), and independent living disability (8.5% vs. 7.7%) compared to those exposed to low levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Regression analyses revealed significantly elevated adjusted prevalence ratios (PRs) for cognitive (PR: 1.09 [95% CI: 1.06\u20131.12], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), mobility (PR: 1.06 [1.03\u20131.10], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), self\u2010care (PR: 1.16 [1.11\u20131.20], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and independent living disability (PR: 1.08 [1.05\u20131.12], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in counties with very high microplastic exposure compared to those with low exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights a significant association between marine microplastic pollution and the self\u2010reported prevalence of cognitive, mobility, self\u2010care, and independent living disabilities at the county level. While merely associative, these findings emphasize the urgent need for further investigation into the individual\u2010level health impacts of microplastic exposure and underscore the importance of environmental interventions to mitigate potential risks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70144","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T13:36:47Z","timestamp":1747834607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Marine Microplastics on Neurologic and Functional Disabilities: A Population\u2010Level Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0215-5300","authenticated-orcid":false,"given":"Bhargav","family":"Makwana","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brinda","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Neurology Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayashri","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Neurology Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Apetauerova","sequence":"additional","affiliation":[{"name":"Department of Neurology Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourbha S.","family":"Dani","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Neurology Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Yerstein","sequence":"additional","affiliation":[{"name":"Department of Neurology Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanth","family":"Khadke","sequence":"additional","affiliation":[{"name":"Department of Medicine Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurram","family":"Nasir","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart &amp; Vascular Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Wadhera","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Kong","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Navas\u2010Acien","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Columbia University Mailman School of Public Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Adamkiewicz","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"Harrington Heart and Vascular Institute University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeer","family":"Al\u2010Kindi","sequence":"additional","affiliation":[{"name":"Center for Health and Nature and Department of Cardiology Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Moffatt\u2010Bruce","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Department of Surgery Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0296-6864","authenticated-orcid":false,"given":"Sarju","family":"Ganatra","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Lahey Hospital &amp; Medical Center  Burlington Massachusetts USA"},{"name":"Sustain Health Solutions  Chelsea Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"ADI \u201cDementia Statistics \u201d accessed September 25 2024 https:\/\/www.alzint.org\/about\/dementia\u2010facts\u2010figures\/dementia\u2010statistics\/."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101504"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512308"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/envhealth.3c00052"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.127629"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113342"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010023\u201003625\u2010z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.133289"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.134261"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.128431"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP10255"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e13070"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.02.062"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/es4053076"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resourpol.2022.103066"},{"key":"e_1_2_10_17_1","unstructured":"Bureau UC \u201cCoastline America \u201d Census.gov accessed October 11 2024 https:\/\/www.census.gov\/library\/visualizations\/2019\/demo\/coastline\u2010america.html."},{"key":"e_1_2_10_18_1","unstructured":"National Centers for Environmental Information (NCEI) \u201cMarine Microplastic Concentration Map Portal Help Page \u201d (2023) https:\/\/www.ncei.noaa.gov\/products\/microplastics\/help."},{"key":"e_1_2_10_19_1","unstructured":"CDC \u201c2021 BRFSS Survey Data and Documentation \u201d (2023) https:\/\/www.cdc.gov\/brfss\/annual_data\/annual_2021.html."},{"key":"e_1_2_10_20_1","unstructured":"PMC \u201cPeer Reviewed: PLACES: Local Data for Better Health \u201d accessed October 11 2024 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9258452\/."},{"key":"e_1_2_10_21_1","unstructured":"PRB \u201cRipple Effects: Population and Coastal Regions \u201d accessed December 1 2024 https:\/\/www.prb.org\/resources\/ripple\u2010effects\u2010population\u2010and\u2010coastal\u2010regions\/."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1163\/092735208X331872"},{"key":"e_1_2_10_23_1","unstructured":"IISD \u201cProtecting the Marine Environment From Land\u2010Based Activities \u201d International Institute for Sustainable Development accessed December 1 2024 https:\/\/www.iisd.org\/articles\/deep\u2010dive\/protecting\u2010marine\u2010environment\u2010land\u2010based\u2010activities."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-73287-x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191710718"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.107772"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gsd.2022.100852"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hydres.2020.06.001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11270-020-04724-6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0016702919110065"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.146752"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010023\u201027461\u20109"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/10807039.2022.2154635"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/10807039.2019.1578947"},{"key":"e_1_2_10_35_1","unstructured":"CDC \u201cGroundwater Awareness Week. Drinking Water \u201d(2024) https:\/\/www.cdc.gov\/drinking\u2010water\/event\u2010name\/groundwater\u2010awareness\u2010week.html."},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.33997\/j.afs.2022.35.3.003"},{"key":"e_1_2_10_37_1","unstructured":"University of Rhode Island \u201cEat Like a Fish \u201dhttps:\/\/www.uri.edu\/magazine\/issues\/summer\u20102019\/eat\u2010like\u2010a\u2010fish\/."},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsh.10818"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46050256"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108172"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2020.105021"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.150817"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.903455"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201042286\u20108"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010015\u20100434\u20101"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.112904"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.126482"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003453\u20101"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102010\u20101245"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00280-3"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309822"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12081298"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:01:23Z","timestamp":1748347283000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/ene.70144"],"URL":"https:\/\/doi.org\/10.1111\/ene.70144","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70144"}}