{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:51:28Z","timestamp":1791204688648,"version":"4.2.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Increased intracranial pressure (ICP) can be observed immediately upon seizure activity in craniotomized patients in neurosurgical practice. However, it is not commonly included in models of pathomechanisms contributing to morbidity and mortality in epilepsy. A main contributor to this may be the fact that measuring ICP noninvasively during a seizure is technically challenging. The optic nerve sheath diameter (ONSD) represents a promising, noninvasive option to monitor relative ICP changes. We therefore measured ONSD in patients undergoing electroconvulsive therapy (ECT).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Twenty\u2010seven ECT\u2010induced seizures from nine consecutive patients underwent ONSD measurement at baseline after induction of anesthesia (t0), during injection of suxamethonium (sux) (t1), after injection of sux (t2), during the electrically induced seizure (t3), and after the electrically induced seizure (t4). A linear mixed model was applied.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n An increase in ONSD of >\u20090.2\u2009mm from t0 to t3 was observed in all patients and in all ECT\u2010induced seizures except one. ONSD increased significantly during the succinylcholine\u2010induced fasciculations, T\n 1<\/jats:sub>\n , (\n \u03b2<\/jats:italic>\n \u2009=\u20090.535\u2009mm,\n p<\/jats:italic>\n \u2009<\u20090.001) and during the electrically induced seizure, T\n 3<\/jats:sub>\n , (\n \u03b2<\/jats:italic>\n \u2009=\u20091.02\u2009mm,\n p<\/jats:italic>\n \u2009<\u20090.001). ONSD returned to baseline after the fasciculations, T\n 2<\/jats:sub>\n , (\n \u03b2<\/jats:italic>\n \u2009=\u20090.091\u2009mm,\n p<\/jats:italic>\n \u2009=\u20090.443) and after the seizure, T\n 4<\/jats:sub>\n , (\n \u03b2<\/jats:italic>\n \u2009=\u20090.103\u2009mm,\n p<\/jats:italic>\n \u2009=\u20090.379).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This investigation shows generalized convulsive seizures are associated with a transient but pronounced increase in ONSD, suggesting a temporary increase in ICP.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.70149","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T06:36:51Z","timestamp":1744785411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Raised Intracranial Pressure in Seizures Induced by Electroconvulsive Therapy"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-4775","authenticated-orcid":false,"given":"Jochem K. H.","family":"Spoor","sequence":"first","affiliation":[{"name":"Deptartment of Neurosurgery Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger V. A.","family":"Hollestelle","sequence":"additional","affiliation":[{"name":"Deptartment of Anesthesiology Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom K.","family":"Birkenhager","sequence":"additional","affiliation":[{"name":"Deptartment of Psychiatry Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"},{"name":"Deptartment of Psychiatry University of Antwerp Collaborative Antwerp Psychiatric Research Institute Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Claire Y.","family":"De Wit","sequence":"additional","affiliation":[{"name":"Deptartment of Pediatric Neurology Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain K.","family":"Haitsma","sequence":"additional","affiliation":[{"name":"Deptartment of Neurosurgery Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M. J.","family":"Mathijssen","sequence":"additional","affiliation":[{"name":"Deptartment of Plastic Surgery Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Lise C.","family":"van Veelen","sequence":"additional","affiliation":[{"name":"Deptartment of Neurosurgery Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel A.","family":"Kamp","sequence":"additional","affiliation":[{"name":"Deptartment of Palliative and Neuro\u2010Palliative Care Brandenburg Medical School Theodore Fontane R\u00fcdersdorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Pluijms","sequence":"additional","affiliation":[{"name":"Deptartment of Psychiatry Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Klimek","sequence":"additional","affiliation":[{"name":"Deptartment of Anesthesiology Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinze","family":"Neuteboom","sequence":"additional","affiliation":[{"name":"Deptartment of Pediatric Neurology Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iscander M.","family":"Maissan","sequence":"additional","affiliation":[{"name":"Deptartment of Anesthesiology Erasmus University Medical Centre Rotterdam Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxine","family":"Dibu\u00e9","sequence":"additional","affiliation":[{"name":"Deptartment of Palliative and Neuro\u2010Palliative Care Brandenburg Medical School Theodore Fontane R\u00fcdersdorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"issue":"11","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1838","article-title":"Sudden Death in Epilepsy: There Is Room for Intracranial Pressure","volume":"10","author":"Dibu\u00e9 M.","year":"2020","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.10.JNS141197"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199303253281204"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0000000000000802"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16966"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12532"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-187"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010198608000\u201000006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198707000-00009"},{"key":"e_1_2_9_11_1","first-page":"591","article-title":"Non\u2010Invasive Evaluation of Intracranial Pressure by Transcranial Doppler Ultrasound in Patients With Traumatic Brain Injury","volume":"20","author":"Chang T.","year":"2020","journal-title":"Chinese Journal of Contemporary Neurology and Neurosurgery"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2023.109264"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5325"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2008.05.006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00975.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2010.06.039"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14621"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16519"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010022\u201001462\u2010x"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:58:23Z","timestamp":1791201503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/ene.70149"],"URL":"https:\/\/doi.org\/10.1111\/ene.70149","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70149"}}