{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:51:20Z","timestamp":1791204680111,"version":"4.2.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the association between postoperative lesions in distinct ROIs of the brain and the impact that their ablation would have on the structural and functional brain connectivity relative to outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 21 patients with refractory unilateral MTLE. The percentage of each ablated gray matter region of interest (ROIs) was calculated, using a voxel\u2010by\u2010voxel comparison. The percentage of the affected fibers was calculated by assessing the neuronal change reflected by a decrease in anisotropy in the repeat scans (i.e., pre and postoperative). Graph theory analysis was used to investigate the change in the pre and postoperative structural and functional networks between the seizure\u2010free and non\u2010seizure\u2010free groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen patients (71.42%) were seizure\u2010free and six (28.57%) were non\u2010seizure\u2010free at a 12 to 48\u2009months (23.80\u2009\u00b1\u20098.93) follow\u2010up. Four patients (19.04%) reported memory decline following RFTC. The seizure\u2010free group showed a larger ablation volume of both the amygdala (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024) and rhinal cortex (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035), and an alteration in structural connectivity networks metrics (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) compared to the non\u2010seizure\u2010free group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study shows that a higher ablation of both the amygdala and rhinal cortex led to improved structural connectivity and was associated with better outcomes. Our results provide insight into some essential elements of brain connectivity networks in MTLE and might contribute to the generation of novel evidence that could improve SEEG\u2010guided RFTC interventions in MTLE patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70153","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T06:40:16Z","timestamp":1745217616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Change in Structural Connectivity Following Stereotactic Thermocoagulation in Mesial Temporal Lobe Epilepsy Patients"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4859-0189","authenticated-orcid":false,"given":"St\u00e9phane","family":"Jean","sequence":"first","affiliation":[{"name":"Pediatric Epilepsy Center Fujian Medical University Fuzhou Children's Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-0027","authenticated-orcid":false,"given":"Rifeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2150-9522","authenticated-orcid":false,"given":"Yihai","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5598-5930","authenticated-orcid":false,"given":"Weitao","family":"Chen","sequence":"additional","affiliation":[{"name":"Pediatric Epilepsy Center Fujian Medical University Fuzhou Children's Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2246-4226","authenticated-orcid":false,"given":"Weihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Pediatric Epilepsy Center Fujian Medical University Fuzhou Children's Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3477-2362","authenticated-orcid":false,"given":"Donghuo","family":"Deng","sequence":"additional","affiliation":[{"name":"Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1471-3892","authenticated-orcid":false,"given":"Panashe Tevin","family":"Tagu","sequence":"additional","affiliation":[{"name":"Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7046-0554","authenticated-orcid":false,"given":"Xiaoqiang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8091-8665","authenticated-orcid":false,"given":"Shan","family":"Chen","sequence":"additional","affiliation":[{"name":"Pediatric Epilepsy Center Fujian Medical University Fuzhou Children's Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6742-3015","authenticated-orcid":false,"given":"Xinrong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-8914","authenticated-orcid":false,"given":"Shiwei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.9.1683"},{"key":"e_1_2_14_3_1","first-page":"609","volume-title":"Surgical Treatment of the Epilepsies","author":"Engel J.","year":"1993"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh221"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500136"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.8.gks141608"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010017\u20100772\u20108"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh449"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17440"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10309\u2010019\u201000302\u2010x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12866"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.45.7.1358"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.51.2.465"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004\u2010282x2004000100003"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16310"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2008.01604.x"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16694"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2006.00958.x"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.0204"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2011.03298.x"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.01.028"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14528"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25888"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000435306.95271.5f"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2009.02397.x"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2023.11.014"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.039"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116131"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.003"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.04.004"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510619112"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920\u20101211(90)90009\u2010k"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24376"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.12.focus11342"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000013033"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/317623a0"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51620"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae141"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102012\u2010302476"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2237"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq291"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17059"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010018\u20100663\u2010y"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13867"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.3.jns19350"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23153"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.10.025"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17613"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17171"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:58:45Z","timestamp":1791201525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/ene.70153"],"URL":"https:\/\/doi.org\/10.1111\/ene.70153","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70153"}}