{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:51:28Z","timestamp":1791204688635,"version":"4.2.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["ANR\u201021\u2010JPW2\u20100002\u201001"],"award-info":[{"award-number":["ANR\u201021\u2010JPW2\u20100002\u201001"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Changes over time in the incidence of Motor Neuron Disease (MND) remain uncertain. We aimed to examine time trends in the incidence and survival of MND over 14\u2009years using the Syst\u00e8me National des Donn\u00e9es de Sant\u00e9, a nationwide French administrative database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We utilized a published algorithm that integrates riluzole prescriptions and hospital discharge to identify incident MND cases from January 1, 2010, to December 31, 2023. Crude and standardized incidences were calculated per 100,000 person\u2010years. Multivariate Poisson regression models determined time trends in MND incidence by age and sex. Survival was analyzed using Kaplan\u2013Meier methods and Cox proportional hazards models to calculate adjusted hazard ratios for different time periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 30,028 incident cases were identified. Crude incidence rose from 2.99 to 3.49 cases per 100,000 person\u2010years between 2010 and 2019, reflecting an annual increase of 1.7% (IRR 1.017, 95% CI 1.012\u20131.021). After accounting for population aging, there was still an annual increase of 0.7% (IRR: 1.007 [95% CI 1.002\u20131.012]) between 2010 and 2019. From 2020 to 2023, observed incidence rates deviated from the expected trend, particularly in 2022, which showed a 15% decrease. The median survival time after diagnosis was 18.1\u2009months (2010), 17.8\u2009months (2015), and 15.6\u2009months (2019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although population aging explains much of the rise in case numbers, it does not fully account for the increase. Mortality rates remained stable between 2010 and 2015, but the COVID\u201019 pandemic had a notable impact, leading to reduced incidence and survival rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70156","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T06:40:31Z","timestamp":1744785631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Time Trends in Incidence of Motor Neuron Diseases in France: A Comprehensive 14\u2010Year Nationwide Study (2010\u20132023)"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1876-2948","authenticated-orcid":false,"given":"Octave","family":"Guinebretiere","sequence":"first","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, Inria Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Calonge","sequence":"additional","affiliation":[{"name":"Paris Brain Institute\u2014Institut du Cerveau, ICM, INSERM, CNRS, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Sorbonne Universit\u00e9  Paris France"},{"name":"AP\u2010HP, Epilepsy Unit Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, DMU Neurosciences  Paris France"},{"name":"AP\u2010HP, Center of Reference for Rare Epilepsies Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Bruneteau","sequence":"additional","affiliation":[{"name":"Department of Neurology, Assistance Publique H\u00f4pitaux de Paris (APHP), centre de r\u00e9f\u00e9rence SLA Ile de France H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re, DMU Neurosciences  Paris France"},{"name":"Institut National de La Sant\u00e9 Et de La Recherche M\u00e9dicale, Association Institut de Myologie, Centre de Recherche en Myologie, UMRS974 Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Del\u2010Mar","family":"Amador","sequence":"additional","affiliation":[{"name":"Department of Neurology, Assistance Publique H\u00f4pitaux de Paris (APHP), centre de r\u00e9f\u00e9rence SLA Ile de France H\u00f4pital de la Piti\u00e9\u2010Salp\u00eatri\u00e8re, DMU Neurosciences  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-2879","authenticated-orcid":false,"given":"Thomas","family":"Nedelec","sequence":"additional","affiliation":[{"name":"Paris Brain Institute\u2014ICM, Inserm, CNRS, Inria Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30404-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010024\u201012219\u20101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)61156\u20107"},{"key":"e_1_2_9_5_1","first-page":"225","volume-title":"Handbook of Clinical Neurology","author":"Talbott E. O.","year":"2016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2017.1306566"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2021.1883669"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.183525"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493386"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw061"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12743-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2024.2336127"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02623.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010011\u20106390\u20105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000343008.26874.d1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2022.2040533"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2024.2401621"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16465"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-023-02148-w"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.03.028"},{"key":"e_1_2_9_21_1","unstructured":"INSEE \u201cOp\u00e9ration Statistique: Estimations de Population \u201dhttp:\/\/www.insee.fr\/fr\/methodes\/default.asp?page1\/4sources\/ope\u2010adm\u2010estimations\u2010population.htm."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2022.05.004"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2018.1550517"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25276"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012632"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09190-7"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100014955"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960902721626"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100005813"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.2.280"},{"issue":"3","key":"e_1_2_9_31_1","first-page":"86","article-title":"Impact of COVID\u201019 Pandemic on Chronic Diseases Care Follow\u2010Up and Current Perspectives in Low Resource Settings: A Narrative Review","volume":"13","author":"Fekadu G.","year":"2021","journal-title":"International Journal of Physiology, Pathophysiology and Pharmacology"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckac107"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:58:35Z","timestamp":1791201515000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/ene.70156"],"URL":"https:\/\/doi.org\/10.1111\/ene.70156","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70156"}}