{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:51:33Z","timestamp":1791204693302,"version":"4.2.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stroke is a major global health concern, particularly for women of childbearing age (WCBA), who face unique biological and sociodemographic risks. This study analyzes temporal trends in stroke incidence, prevalence, disability\u2010adjusted life\u2010year (DALY), and deaths among WCBA at global, regional, and national levels over the past three decades, using age\u2013period\u2013cohort (APC) modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Stroke burden data for WCBA from 1992 to 2021 across 204 countries were extracted from the Global Burden of Disease (GBD) 2021 study. An APC model assessed annual percentage changes in stroke burden (net drift), age group\u2010specific trends (local drift), and relative risks associated with age, period, and cohort factors. Future stroke burden was projected using Bayesian APC models through 2030.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 1992 to 2021, global stroke incidence cases among WCBA increased from 638,478 to 779,371, but ASIR and AS\u2010DALYs declined. High\u2010SDI regions consistently had the lowest stroke rates, while middle\u2010 and low\u2010SDI regions, particularly China and India, accounted for a significant portion of global cases. Despite declines in some regions, countries like the Philippines and Pakistan exhibited rising trends. Projections to 2030 indicate a continued increase in stroke incidence cases, with higher rates expected in middle\u2010income countries due to emerging risk factors like obesity and gestational diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While ASIR and AS\u2010DALYs declined globally, rising incidence case numbers and persistent disparities highlight the need for targeted prevention and policy strategies, particularly in low\u2010 and middle\u2010income regions, to reduce the stroke burden among WCBA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70159","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T03:25:41Z","timestamp":1744428341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Global Temporal Trends and Projections of Stroke 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