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In our study, we propose a new variable echo time (vTE) MRI sequence as a non\u2010invasive method to detect nerve injury in ATTRv patients and to establish a novel potential imaging marker of neuropathy that correlates with disease severity and abnormal results of NCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cohort study, twenty patients with clinically confirmed ATTRv polyneuropathy (PNP) and twenty\u2010one healthy volunteers underwent 3\u2009T MRI. vTE was performed on the right thigh to include the proximal tract of the sciatic nerve. The cross\u2010sectional area of the whole sciatic nerve, inner epineurium, and endoneurial fascicles was segmented, and the corresponding pseudo\u2010T2* was extrapolated from the two acquired echoes of the vTE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significantly higher fascicles pT2* (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.001), total cross\u2010sectional area (CSA:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and fascicular area (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.001) were found in the ATTRv group compared to healthy controls. Fascicles pT2* also correlated with previously validated clinical outcome measures such as Polyneuropathy Disability Scoring System (PND score\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090. 001), Neuropathy Impairment Score (NIS\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) and NIS items related to the lower limbs, and with nerve conduction parameters, demonstrating the ability to discriminate ATTRv patients with different degrees of PNP from HC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, the vTE sequence provides novel and reliable imaging markers capable of detecting early nerve microstructural changes related to disease onset and severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70172","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T07:54:57Z","timestamp":1745394897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quantitative\n                    <scp>MRI<\/scp>\n                    Assessment Using Variable Echo Time Imaging of Peripheral Nerve Injury in\n                    <scp>ATTRv<\/scp>\n                    Amyloidosis Patients"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-3293","authenticated-orcid":false,"given":"Carlo","family":"Asteggiano","sequence":"first","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Advanced Imaging and Artificial Intelligence Center IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Paoletti","sequence":"additional","affiliation":[{"name":"Advanced Imaging and Artificial Intelligence Center IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8776-6831","authenticated-orcid":false,"given":"Elisa","family":"Vegezzi","sequence":"additional","affiliation":[{"name":"IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xeni","family":"Deligianni","sequence":"additional","affiliation":[{"name":"Basel Muscle MRI. Department of Biomedical Engineering University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Santini","sequence":"additional","affiliation":[{"name":"Basel Muscle MRI. Department of Biomedical Engineering University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Bergsland","sequence":"additional","affiliation":[{"name":"Buffalo Neuroimaging Analysis Center, Department of Neurology Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Papinutto","sequence":"additional","affiliation":[{"name":"Weill Institute for Neurosciences, Department of Neurology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6527-3558","authenticated-orcid":false,"given":"Massimiliano","family":"Todisco","sequence":"additional","affiliation":[{"name":"Translational Neurophysiology Research Unit IRCCS Mondino Foundation  Pavia 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