{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:31:53Z","timestamp":1753878713877,"version":"3.41.2"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011542","name":"Center for Clinical and Translational Science, Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Idiopathic inflammatory myopathies, beyond inclusion body myositis (IBM<\/jats:styled-content>), have demonstrated an increased risk of adverse cardiovascular outcomes, particularly myocardial infarction (MI<\/jats:styled-content>). This study evaluated the risk of cardiovascular disease in IBM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a non\u2010concurrent cohort study utilizing the expanded Rochester Epidemiologic Project, including 50 patients with IBM<\/jats:styled-content>, matched 1:6 to age\u2010, sex\u2010, and calendar year\u2010matched referents without IBM<\/jats:styled-content>. Baseline cardiovascular risk factors were recorded. Differences in baseline covariates were adjusted by the inverse probability of treatment weighting method. Participants were followed from the index date forward to determine relative risks (RR<\/jats:styled-content>) and hazard ratios (HR<\/jats:styled-content>) for the development of cardiovascular outcomes including MI<\/jats:styled-content>, ischemic stroke, cardiomyopathy, congestive heart failure (CHF<\/jats:styled-content>), and peripheral vascular disease (PVD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>50 patients with IBM<\/jats:styled-content> and 294 matched population referents were included. Baseline cardiovascular risk factors were similar between groups. Aspirin use was more common (28% vs. 18%, p<\/jats:italic>\u2009=\u20090.03) and statin use less common (26% vs. 38%, p<\/jats:italic>\u2009=\u20090.04) in IBM<\/jats:styled-content> versus referents. Patients with IBM<\/jats:styled-content> had an increased hazard of MI<\/jats:styled-content> compared to referents [HR<\/jats:styled-content>: 5.79, 95% CI<\/jats:styled-content> (2.51, 13.36)]. The risk of MI<\/jats:styled-content> remained consistently elevated across all models, after accounting for potential confounders. For PVD<\/jats:styled-content>, 16\/50 IBM<\/jats:styled-content> patients versus 16\/287 referents were excluded due to pre\u2010existing PVD<\/jats:styled-content> at index (p<\/jats:italic>\u2009<\u20090.001). Among remaining participants, RR<\/jats:styled-content> for PVD<\/jats:styled-content> was 2.38 (0.82, 6.9). IBM<\/jats:styled-content> was not associated with an increased risk of ischemic stroke, cardiomyopathy, or CHF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>IBM<\/jats:styled-content> is associated with increased risk of MI<\/jats:styled-content> compared to population referents. Heightened cardiovascular monitoring and prevention strategies are needed in IBM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70177","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T09:05:47Z","timestamp":1745917547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased Risk of Myocardial Infarction in Inclusion Body Myositis: A Non\u2010Concurrent Cohort Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-1796","authenticated-orcid":false,"given":"Grayson","family":"Beecher","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"},{"name":"Division of Neurology, Department of Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Shammas","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alanna M.","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA"},{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Mandrekar","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"},{"name":"Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Harmsen","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-1236","authenticated-orcid":false,"given":"Elie","family":"Naddaf","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0186-x"},{"key":"e_1_2_9_3_1","first-page":"445","article-title":"Epidemiology of Sporadic Inclusion Body Myositis and Polymyositis in Olmsted County, Minnesota","volume":"35","author":"Wilson F. 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