{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:36:17Z","timestamp":1793975777212,"version":"4.8.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Amyloid positron emission tomography (PET) is instrumental in achieving an accurate diagnosis and may help to limit health\u2010seeking behavior. Currently, amyloid\u2010PET is not routinely used in clinical practice due to lack of evidence on cost\u2010utility. We assessed the cost\u2010utility of early versus no amyloid\u2010PET in the diagnostic work\u2010up of memory clinic patients after 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed cost\u2010utility of patients enrolled in AMYPAD\u2010DPMS (EudraCT Number: 2017\u2010002527\u201021) from six European memory clinics and randomized in ARM1; early amyloid\u2010PET, ARM2; no amyloid\u2010PET or ARM3; (amyloid\u2010PET at request of the managing physician). ARM3 was not part of the cost\u2010utility analysis. The EuroQol classification system (EQ\u20105D\u20105L), visual analogue scale (VAS), and ICEpop Capability measure for older people (ICECAP\u2010O) were collected at baseline and 6 months. Costs were calculated from cost diaries at baseline, 3 and 6 months. The incremental cost\u2010effectiveness ratio (ICER) was calculated using EQ\u20105D\u20105L and a societal perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From April 2018, to October 2020, 844 participants were screened and 840 were randomized (290 ARM1; 270 ARM2 and 280 ARM3). <jats:italic>N<\/jats:italic>\u2009=\u2009514 (250 ARM1; 264 ARM2) were included in the economic evaluation. Amyloid\u2010PET resulted in higher costs at 6\u2009months (ARM1 vs. ARM2 \u2206\u20ac1384, bootstrapped 95% CI [7, 2761]). No significant difference in EQ\u20105D\u20105L, VAS or ICECAP\u2010O was found. The incremental cost\u2010effectiveness ratio (ICER) was \u20ac461,333 per QALY.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although patients receive an early etiological diagnosis, the cost\u2010utility after 6\u2009months is not favorable for amyloid\u2010PET. The cost\u2010utility will need to be reassessed when considering amyloid\u2010PET to select patients for anti\u2010amyloid biologics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70197","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T05:49:01Z","timestamp":1750744141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Utility, Costs and Cost\u2010Utility of Amyloid\u2010<scp>PET<\/scp> in the Diagnostic Process of Memory Clinic Patients: A Trial\u2010Based Economic Evaluation From <scp>AMYPAD<\/scp>\u2010<scp>DPMS<\/scp>"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6919-8340","authenticated-orcid":false,"given":"Ingrid S.","family":"van Maurik","sequence":"first","affiliation":[{"name":"Alzheimer Center Amsterdam Neurology Amsterdam UMC Location VUmc Vrije Universiteit Amsterdam  the Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration Amsterdam  the Netherlands"},{"name":"Amsterdam UMC, Vrije Universiteit Amsterdam Department of Epidemiology and Data Science Amsterdam Public Health Institute Amsterdam  the Netherlands"},{"name":"Northwest Academy Northwest Clinics Alkmaar  Alkmaar the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Altomare","sequence":"additional","affiliation":[{"name":"Competence Centre on Ageing (CCA), Department of Business Economics, Health and Social Care (DEASS) University of Applied Sciences and Arts of Southern Switzerland (SUPSI)  Manno Switzerland"},{"name":"Laboratory of Neuroimaging of Aging (LANVIE) University of Geneva  Geneva Switzerland"},{"name":"Geneva Memory Center Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyduine E.","family":"Collij","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Amsterdam University Medical Center, Amsterdam Neuroscience  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience, Brain Imaging  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilia","family":"Caprioglio","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging of Aging (LANVIE) University of Geneva  Geneva Switzerland"},{"name":"Geneva Memory Center Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Moro","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroimaging of Aging (LANVIE) University of Geneva  Geneva Switzerland"},{"name":"Geneva Memory Center Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Garibotto","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Department of Medical Imaging University Hospitals of Geneva  Geneva Switzerland"},{"name":"NIMTlab, Faculty of Medicine Geneva University  Geneva Switzerland"},{"name":"CIBM Center for Biomedical Imaging  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Demonet","sequence":"additional","affiliation":[{"name":"Leenaards Memory Center Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Scheltens","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Neurology Amsterdam UMC Location VUmc Vrije Universiteit Amsterdam  the Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration Amsterdam  the Netherlands"},{"name":"EQT Life Sciences  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Farrer","sequence":"additional","affiliation":[{"name":"GE Healthcare  Amersham 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Luis","family":"Molinuevo","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"H. Lundbeck A\/S  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Grau\u2010Rivera","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Hospital del Mar Medical Research Institute (IMIM)  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-2002","authenticated-orcid":false,"given":"Paul","family":"Edison","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Brain Sciences Imperial College London  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Walker","sequence":"additional","affiliation":[{"name":"Division of Psychiatry University College London  London UK"},{"name":"St. 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