{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:31:19Z","timestamp":1753878679335,"version":"3.41.2"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["431549029\u2010SFB 1451"],"award-info":[{"award-number":["431549029\u2010SFB 1451"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The motor\u2010cognitive syndrome apraxia is a common stroke sequela and severely affects the outcome after stroke by impairing activities of daily living. Notably, like in many health conditions, there is a massive backlog regarding studies on sex differences in patients with apraxia despite common knowledge that sex influences praxis performance in healthy participants. We investigated putative sex differences in apraxic stroke patients at the behavioral and neural levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed the data of a cohort of 102 left\u2010hemisphere stroke patients in the (sub)acute phase who were apraxic according to the Cologne Apraxia Screening (KAS). We conducted voxel\u2010based lesion\u2013symptom mapping (VLSM) to elucidate the lesion patterns. Further, in an age\u2010matched subsample (tolerance of 5\u2009years) with equal numbers of men and women, behavioral comparisons and a VLSM analysis were conducted to explore differential sex\u2010related lesion patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, apraxic deficits were associated with lesions in the parietal, temporal, and frontal regions in the cohort of 102 left\u2010hemisphere stroke patients. The age\u2010matched cohort consisted of 30 women and 30 men and showed no significant differences in demographic and clinical characteristics. There were no performance differences between men and women at the behavioral level regarding praxis functions. In contrast, VLSM revealed differential lesion patterns by sex. Male compared to female apraxic stroke patients significantly more often showed lesions that affected the left inferior frontal gyrus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data suggest a differential organization of the praxis system in men and women, warranting further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70201","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T12:55:08Z","timestamp":1748004908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential Lesion Patterns Associated With Stroke\u2010Induced Apraxia in Women and Men"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-878X","authenticated-orcid":false,"given":"Nina N.","family":"Kleineberg","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"},{"name":"Cognitive Neuroscience Institute of Neurosciences and Medicine (INM\u20103), Forschungszentrum J\u00fclich  J\u00fclich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia C.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Institute of Neurosciences and Medicine (INM\u20103), Forschungszentrum J\u00fclich  J\u00fclich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"},{"name":"Cognitive Neuroscience Institute of Neurosciences and Medicine (INM\u20103), Forschungszentrum J\u00fclich  J\u00fclich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of 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