{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:12:33Z","timestamp":1790813553536,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Charcot\u2013Marie\u2013Tooth disease type 1A (CMT1A) is the most common form of CMT, varying from asymptomatic to severe. The aim of this study was to investigate whether the diffusion tensor imaging (DTI) parameters and diameter of the proximal nerves, as measured by magnetic resonance neurography, can be used as a potential marker to reflect the progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study including 45 consecutive patients with CMT1A, divided into three subgroups by foot dorsiflexion muscle strength: mild cases (Group 1), moderate cases (Group 2), and severe cases (Group 3). We compared the diameter, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) of the L4\u2013L5 nerve roots, femoral nerve (FN), and sciatic nerve (SN) of patients with CMT1A with those of healthy controls (HCs), and among subgroups. We followed 19 patients for 15\u2009months and analyzed the change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diameters of the L4 nerve roots and SN were significantly larger in Group 3 than in Group 1 and HCs. FA was decreased and MD and AD were increased significantly in Group 3 compared to Group 1, with the differences being more pronounced in SN and L4 nerve roots. After the follow\u2010up period, the diameters, FA, MD, AD, and RD of the nerve roots were changed significantly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nerve diameter, FA, MD, and AD on DTI could be sensitive measures reflecting disease severity and progression in patients with CMT1A, prominently in proximal nerve roots. SN and L4 nerve roots may be suitable indices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70220","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T10:05:18Z","timestamp":1749809118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nerve Diameter and <scp>DTI<\/scp> Parameters Maybe Potential Markers for Clinical Trial in Patients With Charcot\u2013Marie\u2013Tooth Disease Type <scp>1A<\/scp>"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2655-1728","authenticated-orcid":false,"given":"Yuchen","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurology Peking University Third Hospital  Beijing Haidian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University Third Hospital  Beijing Haidian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-9821","authenticated-orcid":false,"given":"Dongsheng","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University Third Hospital  Beijing Haidian China"},{"name":"Beijing Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases  Beijing Haidian China"},{"name":"Key Laboratory for Neuroscience, National Health Commission\/Ministry of Education Peking University  Beijing Haidian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4021-8744","authenticated-orcid":false,"given":"Xiaoxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Peking University Third Hospital  Beijing Haidian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1224","article-title":"Charcot\u2010Marie\u2010Tooth Disease and Other Hereditary Neuropathies","volume":"26","author":"Klein C. 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