{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:09:37Z","timestamp":1787245777198,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>This study evaluates the distribution and prognostic role of transcranial color\u2010coded Doppler (TCCD) spectral patterns following a successful endovascular thrombectomy (EVT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter prospective study included patients with internal carotid or middle cerebral artery (MCA) occlusion treated in the early time window (&lt;\u20096\u2009h) with a successful EVT (mTICI \u2265\u20092b), without symptomatic hemorrhagic transformation within 24\u2009h. TCCDs were performed 24\u201348\u2009h and 7\u2009days from EVT. TCCD flow was graded by Consensus on Grading Intracranial Flow Obstruction (COGIF) score (1: no flow; 2\u20133: low flow; 4a: normal; 4b: residual stenosis; 4c: hyperperfusion). MCA flow velocities were compared between sides and time points. Outcomes were clinical improvement (decrease of 8 points\/30% on day 7 NIHSS vs. baseline) and three\u2010month mRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>188 ischemic stroke patients were included (48% female, median age 77). The median NIHSS was 16 at admission and 3 at day 7. Day 1 TCCD showed slightly higher velocities in the treated MCA compared to the contralateral MCA, without significant differences between day 1 and day 7. Despite mTICI \u2265\u20092b, 13\/187 (7%) patients showed a partial recanalization or residual stenosis at 24\u2009h. Clinical improvement was lacking in 27 patients (14.4%). COGIF scores 3 and 4b at day 1 were significantly associated with lack of improvement at day 7 (aOR 0.03, 95% CI 0.01\u20130.16, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and worse mRS score at 3\u2009months (mRS ordinal shift analysis, aOR 7.78, 95% CI 2.16\u201328.54, <jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Day 1 post\u2010EVT TCCD COGIF score, but no flow velocities alone, are associated with clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70224","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T13:10:15Z","timestamp":1748524215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Value of Cerebral Hemodynamics Assessment on 24\u2010h Transcranial Color\u2010Coded Doppler Following a Successful Thrombectomy"],"prefix":"10.1111","volume":"32","author":[{"given":"Sabrina","family":"Rossi","sequence":"first","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria di Ferrara University Unit of Neurology  Ferrara Italy"},{"name":"Department of Neuroscience and Rehabilitation of Ferrara Azienda Ospedaliero Universitaria di Ferrara Arcispedale Sant\u2018Anna  Cona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-378X","authenticated-orcid":false,"given":"Matteo","family":"Paolucci","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Delle Scienze Neurologiche di Bologna, Department of Neurology and Stroke Center Maggiore Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Arnone","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Delle Scienze Neurologiche di Bologna, Department of Neurology and Stroke Center Maggiore Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5312-7206","authenticated-orcid":false,"given":"Guido","family":"Bigliardi","sequence":"additional","affiliation":[{"name":"Stroke Unit\u2010Clinica Neurologica, Ospedale Civile di Baggiovara Azienda Ospedaliero\u2010Universitaria di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Longoni","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Unit Cesena and Forl\u00ec, Department of Neuroscience AUSL Romagna  Cesena and Forl\u00ec Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pulito","sequence":"additional","affiliation":[{"name":"PO \u201cVito Fazzi\u201d UOC Anestesia e Rianimazione  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Azzini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation of Ferrara Azienda Ospedaliero Universitaria di Ferrara Arcispedale Sant\u2018Anna  Cona Italy"},{"name":"U.O. 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