{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:26Z","timestamp":1787014166534,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>GG homozygosity for the risk gene variant rs7665090 has been reported to enhance nuclear factor kappa B (NF\u03baB) activity in T cells from multiple sclerosis (MS) patients. Here, we investigated the association between this polymorphism and the response to different disease\u2010modifying therapies in MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The rs7665090 polymorphism was genotyped in 558 MS patients treated with injectable therapies [IFN\u03b2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009213) and glatiramer acetate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955)], oral therapies [dimethylfumarate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200997), teriflunomide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941), and fingolimod (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937)], and natalizumab (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009115). Treatment response was assessed after 1\u2009year for injectable therapies using the Rio Score, which considers relapses, EDSS progression, and radiological activity on MRI. For oral therapies and natalizumab, response was evaluated after 2\u2009years based on clinical and radiological disease activity. Univariable and multivariable logistic regression analyses were performed to assess treatment response for each therapy independently.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GG homozygosity was associated with a favorable response outcome in patients treated with IFN\u03b2 in the multivariable analysis after adjusting for age and EDSS at treatment onset [OR 0.42 (0.18\u20130.94);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037]. This finding was restricted to MS patients carrying the GG risk genotype and seemed specific for IFN\u03b2 treatment, since the rs7665090 polymorphism did not influence the response to the other MS therapies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The polymorphism rs7665090 is associated with a favorable response to IFN\u03b2. This study illustrates how genotyping this polymorphism could serve as a useful biomarker in clinical practice to help identify MS patients who are likely to respond favorably to treatment, and encourages further replication in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70227","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T04:27:16Z","timestamp":1752640036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Variant rs7665090 Is Associated With Interferon\u2010Beta Response in Multiple Sclerosis Patients"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8147-8505","authenticated-orcid":false,"given":"Andreu","family":"Vilaseca","sequence":"first","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Urcelay","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Castillo","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Aroca","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-5507","authenticated-orcid":false,"given":"Angela","family":"Vidal\u2010Jordana","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Pappolla","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Arrambide","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Gonz\u00e1lez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"G\u00f3mez\u2010Delgado","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Cobo\u2010Calvo","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona 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Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Villacieros\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Ari\u00f1o","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Castill\u00f3","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-5251","authenticated-orcid":false,"given":"Ana","family":"Zabalza","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7981-2228","authenticated-orcid":false,"given":"Luciana","family":"Midaglia","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delon","family":"La Puma","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1589-2254","authenticated-orcid":false,"given":"Jaume","family":"Sastre\u2010Garriga","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre d'Esclerosi M\u00faltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Tintor\u00e9","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, 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of Multiple Sclerosis: 2017 Revisions of the McDonald Criteria","volume":"17","author":"Thompson A. 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