{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:32:41Z","timestamp":1793968361083,"version":"4.8.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010term continuous monitoring with insertable cardiac monitor (ICM) is recommended after cryptogenic stroke (CS) by current guidelines to detect subclinical atrial fibrillation (SCAF). However, long\u2010term real\u2010world data on ICM\u2010SCAF detection and ensuing therapy are limited. The aim of this study was to assess long\u2010term SCAF detection rate in a large cohort of CS patients with ICM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of consecutive CS patients receiving ICM from September 2016 to February 2024 in 20 Italian centers were collected. Patients were followed with remote and outpatient follow\u2010up according to clinical practice. SCAF was diagnosed if a device\u2010detected SCAF daily burden \u2265\u20095\u2009min was confirmed by a cardiologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven hundred and eighty\u2010nine CS patients with ICM (mean age 69.3\u2009\u00b1\u200911.7\u2009years, 40.3% females, 79.0% CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc score \u2265\u20094) were monitored for a mean of 27.3 (IQR:14.2\u201342.5) months after index stroke. SCAF was diagnosed in 229 (29.0%) patients, with a cumulative detection rate of 37.0% (IQR: 32.9%\u201341.5%) 48\u2009months after the stroke, and was asymptomatic in 198 (86.5%). Sixty\u2010eight (29.7%) patients had one or more days with a 24\u2010h SCAF burden. Median time from index stroke to SCAF diagnosis was 6.9 (IQR: 2.1\u201317.0) months. After SCAF diagnosis, anticoagulants were prescribed to 210 (95.9%) patients out of 219 not already assuming them at baseline. CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc \u2265\u20095, anterior circulation stroke, and cortical lesions were independent predictors of SCAF diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This multicenter real\u2010world project confirmed that ICM allows the detection of SCAF in one third of CS patients 48\u2009months after the stroke, leading to anticoagulation in most of them.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70251","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T05:49:03Z","timestamp":1750225743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010Term Detection of Subclinical Atrial Fibrillation in Cryptogenic Stroke Patients With Insertable Cardiac Monitors"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-8530","authenticated-orcid":false,"given":"Leonardo","family":"Pantoni","sequence":"first","affiliation":[{"name":"Neuroscience Research Center Department of Biomedical and Clinical Sciences, University of Milan  Milan Italy"},{"name":"Department of Neurorehabilitation Sciences Casa di Cura Igea  Milan Italy"},{"name":"Neurology Unit Ospedale Sacco  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mele","sequence":"additional","affiliation":[{"name":"Neurology Unit Ospedale Sacco  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4565-5601","authenticated-orcid":false,"given":"Francesca","family":"Pescini","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurosciences and Sense Organs Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Rafanelli","sequence":"additional","affiliation":[{"name":"Syncope Unit Department of Geriatrics and Intensive Care, Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Zivelonghi","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Unit Neurosciences Department, University Hospital of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Tomasi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Cardio\u2010Thoracic Department School of Medicine, University Hospital of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Mugnai","sequence":"additional","affiliation":[{"name":"Division of Cardiology Cardio\u2010Thoracic Department School of Medicine, University Hospital of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Tomaselli","sequence":"additional","affiliation":[{"name":"Cardiology &amp; ICU Unit \u2013 Civile SS. Annunziata Hospital  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Petrone","sequence":"additional","affiliation":[{"name":"Neurology Unit \u2013 Civile SS. Annunziata Hospital  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Adami","sequence":"additional","affiliation":[{"name":"Stroke Center IRCCS Sacro Cuore Don Calabria Hospital  Negrar di Valpolicella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Molon","sequence":"additional","affiliation":[{"name":"Cardiology Department IRCCS Sacro Cuore Don Calabria Hospital  Negrar di Valpolicella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Crea","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Clinical and Experimental Medicine University Hospital \u201cG. 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