{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:35Z","timestamp":1791388115835,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","award":["IIR\u2010ITA\u2010BXLT\u2010001955\/IISR\u20102017\u2010104226"],"award-info":[{"award-number":["IIR\u2010ITA\u2010BXLT\u2010001955\/IISR\u20102017\u2010104226"]}],"id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Multifocal motor neuropathy (MMN) is a rare motor neuropathy diagnosed by identifying motor conduction block (CB), which may be absent or transient. This study aimed to evaluate nerve conduction abnormalities beyond CB and their diagnostic value.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective analysis included patients fulfilling the 2010 EFNS\/PNS clinical criteria for MMN and controls with axonal polyneuropathy, lower motor neuron disease, or chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Electrophysiological studies evaluated motor distal latency prolongation, reduced motor conduction velocity, prolonged F\u2010wave latency, absence of F\u2010waves, abnormal temporal dispersion, and distal CMAP duration prolongation. The 2010 EFNS\/PNS criteria for MMN were compared to an \u2018extended\u2019 set incorporating additional electrophysiological parameters.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 70\u2009MMN patients and 359 controls were included. At least one nerve conduction abnormality, excluding motor CB, was detected in one or more nerve segments unaffected by CB in 71% of MMN patients, significantly more frequently than in axonal polyneuropathy or lower motor neuron disease patients. These parameters included abnormal temporal dispersion (47%), distal CMAP duration prolongation (31%), reduced motor conduction velocity (26%), absence of F\u2010waves (9%), prolonged F\u2010wave latency (6%), and motor distal latency prolongation (3%). Incorporating these parameters increased sensitivity for diagnosing probable\/definite MMN by 26% (\n p<\/jats:italic>\n \u2009<\u20090.001; compared to EFNS\/PNS criteria), with minimal impact on specificity, even when compared to CIDP patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Including additional electrophysiological parameters into the diagnostic criteria for MMN may enhance diagnostic sensitivity while maintaining comparable specificity. The observation of nerve conduction abnormalities beyond CB indicates a broader electrophysiological profile for MMN.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.70300","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T07:01:40Z","timestamp":1758610900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nerve Conduction Abnormalities Beyond Conduction Block in Multifocal Motor Neuropathy. Impact on Diagnostic Criteria Accuracy"],"prefix":"10.1111","volume":"32","author":[{"given":"Pietro Emiliano","family":"Doneddu","sequence":"first","affiliation":[{"name":"Neuromuscular and Neuroimmunology Unit IRCCS Humanitas Research Hospital Milano Italy"},{"name":"Department of Biomedical Sciences Humanitas University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Gallo","sequence":"additional","affiliation":[{"name":"Neuromuscular and Neuroimmunology Unit IRCCS Humanitas Research Hospital Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Falzone","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Department of Neurology, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Mat\u00e0","sequence":"additional","affiliation":[{"name":"Department of Neurological and Psychiatric Sciences Azienda Ospedaliero\u2010Universitaria di Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cosentino","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia, IRCCS Mondino Foundation Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9805-1655","authenticated-orcid":false,"given":"Vincenzo","family":"Di Stefano","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-7512","authenticated-orcid":false,"given":"Massimiliano","family":"Filosto","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences University of Brescia; 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