{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:38:44Z","timestamp":1791506324121,"version":"4.3.4"},"reference-count":6,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Guillain\u2013Barr\u00e9 Syndrome (GBS) is an autoimmune disease that can cause flaccid tetraplegia. Efgartigimod, a monoclonal antibody that inhibits the neonatal receptor (FcRn), increases IgG degradation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 60\u2010year\u2010old lady was admitted with acute flaccid tetraparesis, requiring mechanical ventilation within 12\u2009h. Nerve conduction studies were compatible with acute inflammatory demyelinating polyneuropathy (AIDP). No anti\u2010ganglioside or anti\u2010nodal\/paranodal antibody could be identified in serum. Despite receiving standard treatment with plasma exchange (PLEX), the patient remained severely tetraparetic, bedridden, and mechanically ventilated. Human immunoglobulin 2\u2009g\/kg was given, without obtaining significant improvement. One month after disease onset, the patient received efgartigimod (10\u2009mg\/kg intravenously) weekly for four doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report the results of this treatment on muscle strength, patient disability, and nerve conduction studies. The tolerability profile was satisfactory, and the patient was able to walk alone after 4\u2009months from disease onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The potential role of efgartigmod in GBS should be explored in future clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70308","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T08:09:13Z","timestamp":1755072553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efgartigimod as Add\u2010On Treatment in Refractory Guillain\u2013Barr\u00e9 Syndrome: A Case Report"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-9656","authenticated-orcid":false,"given":"Paolo","family":"Ripellino","sequence":"first","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland EOC, Ospedale Regionale di Lugano  Lugano Switzerland"},{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Dinacci","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland EOC, Ospedale Regionale di Lugano  Lugano Switzerland"},{"name":"Clinica Hildebrand Centro di riabilitazione  Brissago Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Conti","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana  Lugano Switzerland"},{"name":"Intensive Care Unit, Department of Intensive Care  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland EOC, Ospedale Regionale di Lugano  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Frediani","sequence":"additional","affiliation":[{"name":"Clinica Hildebrand Centro di riabilitazione  Brissago Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana  Lugano Switzerland"},{"name":"Clinica Hildebrand Centro di riabilitazione  Brissago Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-0664","authenticated-orcid":false,"given":"Claudio","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland EOC, Ospedale Regionale di Lugano  Lugano Switzerland"},{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202250336"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97911"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12321-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040700"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562864251314746"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2025.106983"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:51:42Z","timestamp":1756363902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/ene.70308"],"URL":"https:\/\/doi.org\/10.1111\/ene.70308","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70308"}}