{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:02:36Z","timestamp":1756425756921,"version":"3.44.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurological disease usually described in adults. Expanded CAG repeats in the <jats:italic>ATXN2<\/jats:italic> gene can lead to pediatric onset. This study aims to describe the natural history of SCA2 in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed clinical and genetic data from 22 children with SCA2 across 17 institutions and compared them to 20 previously reported cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The phenotype of pediatric SCA2 can be divided into two distinct groups based on CAG repeat size and age. In the infantile group (<jats:italic>n<\/jats:italic>\u2009=\u20099), developmental delay and seizures were prominent features, along with cerebellar and cerebral atrophy. In the juvenile group (<jats:italic>n<\/jats:italic>\u2009=\u200913), the disease was a cerebellar degeneration similar to adults. A threshold of 88\u2009\u00b1\u20094 CAG repeats distinguished the infantile group from the juvenile group. Pediatric SCA2 type was independent of parental origin; SCA2 was maternally inherited in 22%, including three infantile presentations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This large cohort of pediatric SCA2 disease provides the first comprehensive description of its characteristics, which differ from those of SCA7. Indeed, the phenotypic spectrum of SCA7 in children is continuous, while that of SCA2 is bimodal. Although pediatric SCA2 can be difficult to diagnose by genome\u2010wide sequencing, it is a recognizable disease that can be easily diagnosed with a targeted study of the number of CAGs in <jats:italic>ATXN2<\/jats:italic>. Genetic counseling for families should consider the significant proportion of maternal transmission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70314","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T10:55:19Z","timestamp":1753959319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Two Faces of Pediatric <scp>SCA2<\/scp>"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9218-4924","authenticated-orcid":false,"given":"Nicolas","family":"Rive Le Gouard","sequence":"first","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-9447","authenticated-orcid":false,"given":"Maissa","family":"G. Bah","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"},{"name":"APHP, Urgences P\u00e9diatriques CHU Robert Debr\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Coarelli","sequence":"additional","affiliation":[{"name":"Paris Brain Institute, INSERM, CNRS, Assistance Publique\u2010H\u00f4pitaux de Paris (APHP), University Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Heinzmann","sequence":"additional","affiliation":[{"name":"Paris Brain Institute, INSERM, CNRS, Assistance Publique\u2010H\u00f4pitaux de Paris (APHP), University Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Laure","family":"Fauret","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-8226","authenticated-orcid":false,"given":"Jean\u2010Madeleine","family":"de Sainte\u2010Agathe","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Cazeneuve","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gerasimenko","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domitille","family":"Gras","sequence":"additional","affiliation":[{"name":"APHP, CRTLA H\u00f4pital Bic\u00eatre  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yline","family":"Capri","sequence":"additional","affiliation":[{"name":"APHP Service de G\u00e9n\u00e9tique, CHU Robert Debr\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Renaud","sequence":"additional","affiliation":[{"name":"Service de G\u00e9n\u00e9tique Clinique CHU Nancy  Nancy France"},{"name":"INSERM U1256 NGERE \u2010 Nutrition \u2010 G\u00e9n\u00e9tique et Exposition Aux Risques Environnementaux \u2010 Facult\u00e9 de M\u00e9decine \u2010 Universit\u00e9 de Lorraine  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Brais","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Montreal Neurological Hospital and Institute  Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Grenenko","sequence":"additional","affiliation":[{"name":"Service de Neurologie P\u00e9diatrique CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Masurel","sequence":"additional","affiliation":[{"name":"Service de Neurologie P\u00e9diatrique CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Berquin","sequence":"additional","affiliation":[{"name":"Service de Neurologie P\u00e9diatrique CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Jobic","sequence":"additional","affiliation":[{"name":"Service de G\u00e9n\u00e9tique Clinique et Oncog\u00e9n\u00e9tique CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"M\u00e9treau","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Maladies Inflammatoires du Cerveau de L'enfant APHP Universit\u00e9 Paris Saclay, Service de Neurop\u00e9diatrie, H\u00f4pital Bic\u00eatre  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumaran","family":"Deiva","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Maladies Inflammatoires du Cerveau de L'enfant APHP Universit\u00e9 Paris Saclay, Service de Neurop\u00e9diatrie, H\u00f4pital Bic\u00eatre  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Afenjar","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"},{"name":"Centre de R\u00e9f\u00e9rence Des Malformations et Maladies Cong\u00e9nitales du Cervelet  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Gravrand","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-8674","authenticated-orcid":false,"given":"Annie","family":"Lannuzel","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie CHU de Guadeloupe  Pointe\u2010\u00e0\u2010Pitre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Anheim","sequence":"additional","affiliation":[{"name":"Neurology Department Strasbourg University Hospital  Strasbourg France"},{"name":"Strasbourg Federation of Translationa lMedicine Strasbourg University  Strasbourg France"},{"name":"Institute of Genetics and Cellular and Molecular Biology, INSERM\u2010U964; CNRS\u2010UMR7104 University of Strasbourg  Illkirch\u2010Graffenstaden France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Geis","sequence":"additional","affiliation":[{"name":"University Children's Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John University of Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Hehr","sequence":"additional","affiliation":[{"name":"Centre for Human Genetics  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Madan Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neurology at Connecticut Children's University of Connecticut  Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Desnous","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology, La Timone Children Hospital Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke","family":"J. A. Kievit","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Erasmus Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Bahi\u2010buisson","sequence":"additional","affiliation":[{"name":"APHP Service de Neurologie P\u00e9diatrique, DMU MICADO, H\u00f4pital Necker Enfants Malades  Paris France"},{"name":"INSERM U1163, Institut Imagine Universit\u00e9 de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Des Malformations et Maladies Cong\u00e9nitales du Cervelet  Paris France"},{"name":"Service de Neurop\u00e9diatrie, H\u00f4pital Armand Trousseau APHP Sorbonne Universit\u00e9  Paris France"},{"name":"Centre de R\u00e9f\u00e9rence Maladie Rares Neurog\u00e9n\u00e9tique H\u00f4pital Armand Trousseau  Paris France"},{"name":"Inserm U1141\u2010 FHU I2\u2010D2  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Renaldo","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Des Malformations et Maladies Cong\u00e9nitales du Cervelet  Paris France"},{"name":"Service de Neurop\u00e9diatrie, H\u00f4pital Armand Trousseau APHP Sorbonne Universit\u00e9  Paris France"},{"name":"Centre de R\u00e9f\u00e9rence Maladie Rares Neurog\u00e9n\u00e9tique H\u00f4pital Armand Trousseau  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Cances","sequence":"additional","affiliation":[{"name":"Service de Neurop\u00e9diatrie, AOC (Atlantic\u2010Oceania\u2010Caribbean), centre de R\u00e9f\u00e9rence Des Maladies Neuromusculaires CHU de Toulouse  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Devos","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Expert Center of Parkinson's Disease, ALS, and Neurogenetics University of Lille, CHU of Lille, INSERM U1172  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chlo\u00e9","family":"Angelini","sequence":"additional","affiliation":[{"name":"Reference Center for Rare Disease \u201cNeurogenetics\u201d, Department of Medical Genetics Bordeaux University Hospital (CHU Bordeaux)  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Goizet","sequence":"additional","affiliation":[{"name":"Reference Center for Rare Disease \u201cNeurogenetics\u201d, Department of Medical Genetics Bordeaux University Hospital (CHU Bordeaux)  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Ewenczyk","sequence":"additional","affiliation":[{"name":"Paris Brain Institute, INSERM, CNRS, Assistance Publique\u2010H\u00f4pitaux de Paris (APHP), University Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Durr","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"},{"name":"Paris Brain Institute, INSERM, CNRS, Assistance Publique\u2010H\u00f4pitaux de Paris (APHP), University Hospital Piti\u00e9\u2010Salp\u00eatri\u00e8re Sorbonne University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Mignot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique m\u00e9dicale, H\u00f4pital Armand Trousseau et Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re APHP Sorbonne Universit\u00e9  Paris France"},{"name":"Centre de R\u00e9f\u00e9rence Des Malformations et Maladies Cong\u00e9nitales du Cervelet  Paris France"},{"name":"Centre de R\u00e9f\u00e9rence D\u00e9ficiences Intellectuelles de Causes Rares  Paris France"},{"name":"INSERM, U 1127, CNRS UMR 7225 Sorbonne Universit\u00e9, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau, ICM  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00068\u20106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/CGE.13978"},{"volume-title":"Spinocerebellar Ataxia","year":"2023","author":"Bhandari J.","key":"e_1_2_9_4_1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JNS.2020.117082"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ACN3.437"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.156"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.5.1497"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.504"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/NG1196\u2010269"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/NG1196\u2010285"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/NG1196\u2010277"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.5131"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELLSIG.2008.05.018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0660\u201009.2009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNINS.2016.00572"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09320"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000269323.21969.db"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.10"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u20104685\u2010GMB\u20102019\u20100325"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh586"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.231"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000155"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/S004150050385"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073813509015"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073808315622"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.639"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822e5627"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20428"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10467"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807304702"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010008\u20100080\u20106"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010011\u20100315\u20109"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010008\u20100690\u20104"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u20108628(19981012)79:5<383::AID\u2010AJMG10>3.0.CO;2\u2010N"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12050"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa139"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311\u2010015\u20100687\u20103"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ENE.14405"},{"key":"e_1_2_9_40_1","unstructured":"A. R.La Spada \u201cSpinocerebellar Ataxia Type 7 \u201d(1993)."},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13699"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:52:01Z","timestamp":1756363921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/ene.70314"],"URL":"https:\/\/doi.org\/10.1111\/ene.70314","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"type":"print","value":"1351-5101"},{"type":"electronic","value":"1468-1331"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"2025-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70314"}}