{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:47:40Z","timestamp":1779911260571,"version":"3.53.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>7 Tesla (7\u2009T) magnetic resonance imaging (MRI) offers higher spatial resolution and signal\u2010to\u2010noise ratio, enhancing visualization of multiple sclerosis (MS) lesions, including cortical and deep gray matter lesions. It improves detection of MS biomarkers like paramagnetic rim lesions (PRLs) and central vein sign (CVS). Costs have impacted its adoption and experience in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To present real\u2010life data on the routine clinical use of 7\u2009T MRI and its impact on patient management from a single\u2010center perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study, approved by the local ethics committee (KEK Bern No 2020\u201302902), analyzed referrals for 7\u2009T MRI (06\/2020\u201306\/2024) at University Hospital Bern for suspected CNS inflammatory disorders. Imaging reports were compared to clinical data from medical records. Statistical analysis evaluated the diagnostic value of 7\u2009T MRI, focusing on sensitivity, specificity, Negative Predictive Value (NPV), and Positive Predictive Value (PPV). Exclusions included contraindications for 7\u2009T MRI, incomplete medical records, or non\u2010CNS conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>61 patients underwent 7\u2009T MRI, enabling lesion reclassification and MS diagnosis in 19\/47 patients with indefinite diagnosis despite extensive diagnostic workup with adequate 3\u2009T MRI. In 14 MS patients, it clarified diagnostic uncertainties, leading to diagnosis revision in 1\/14 patients and informed treatment decisions in 4\/14 (including treatment escalation (3\/14) and discontinuation (1\/14)). 7\u2009T MRI showed 89.5% sensitivity and 78.6% specificity for MS (PPV 73.9%, NPV 91.7%). MS patients were more likely to exhibit CVS and PRLs compared to non\u2010MS patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>7\u2009T MRI enhances MS diagnosis certainty in diagnostically challenging cases, potentially impacting clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70330","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:49:38Z","timestamp":1756104578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["7 Tesla <scp>MRI<\/scp> in Multiple Sclerosis: Insights From Its Use in Clinical Routine"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8375-9810","authenticated-orcid":false,"given":"A.","family":"Le\u00f3n Betancourt","sequence":"first","affiliation":[{"name":"Department of Neurology Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-6548","authenticated-orcid":false,"given":"F.","family":"Messmer","sequence":"additional","affiliation":[{"name":"Support Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Wiest","sequence":"additional","affiliation":[{"name":"Support Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology University of Bern  Bern Switzerland"},{"name":"Department of Diagnostic and Interventional Neuroradiology, Inselspital Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"Translational Imaging Center Swiss Institute for Translational and Entrepreneurial Medicine  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bonanno","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Inselspital Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"Translational Imaging Center Swiss Institute for Translational and Entrepreneurial Medicine  Bern Switzerland"},{"name":"Swiss Innovation Hub Siemens Healthineers Intl. AG  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Capiglioni","sequence":"additional","affiliation":[{"name":"Support Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hoepner","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital, Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-4814","authenticated-orcid":false,"given":"F.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Inselspital Bern University Hospital and University of Bern  Bern Switzerland"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University 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