{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:44:59Z","timestamp":1779205499879,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peripheral neuropathies encompass a diverse group of disorders involving peripheral nerve damage, often leading to pain, sensory disturbances, and motor impairments. The etiology is multifactorial, with trauma as a key contributor. The treatment of peripheral neuropathies includes medications targeting the nociceptive component, whereas the neuropathic component is managed with agents such as gabapentinoids or antidepressants, though their prolonged use is limited by significant side effects. Some neuroprotective compounds, such as acetyl\u2010L\u2010carnitine (ALC), palmitoylethanolamide (PEA), and alpha\u2010lipoic acid (ALA), have emerged as potential alternatives due to their anti\u2010inflammatory and analgesic properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This monocentric, observational, single\u2010arm longitudinal study evaluated the efficacy of a fixed combination containing ALC, PEA, and ALA (as an adjuvant to the previous two) and <jats:italic>Boswellia serrata<\/jats:italic>, Vitamin E, and Vitamin B6 in patients with acute low back trauma. Over 8\u2009weeks, 48 participants received the supplement alongside conventional therapy. The primary end point was improvement in neuropathic pain assessed via the Neuropathic Pain Scale (NPS) and Visual Analogue Scale (VAS). Secondary endpoints included quality of life (SF\u201036) changes, reduced NSAID consumption, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study showed significant reductions in NPS and VAS scores and improvements in physical health\u2010related SF\u201036 domains, with reduced NSAID consumption. Participants with more severe baseline symptoms demonstrated the greatest benefits. No significant changes were observed in emotional parameters. Adverse events were mild and in a very limited number of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results suggest the combination's potential to improve pain and reduce reliance on conventional therapies; however, further controlled randomized trials are needed to validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70334","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T12:55:57Z","timestamp":1756126557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unlocking Relief: Investigating the Impact of a Fixed Combination of Acetyl\u2010L\u2010Carnitine and Palmitoylethanolamide on Traumatic Acute Low Back Pain"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4315-0282","authenticated-orcid":false,"given":"Mattia","family":"Cominacini","sequence":"first","affiliation":[{"name":"Department of Engineering for Innovation Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1166-8033","authenticated-orcid":false,"given":"Maria Teresa","family":"Valenti","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicines and Movement Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Braggio","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicines and Movement Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Caramori","sequence":"additional","affiliation":[{"name":"Functional Recovery and Rehabilitation Unit Azienda Ospedaliera Universitaria Integrata di Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ermes","family":"Vedovi","sequence":"additional","affiliation":[{"name":"Functional Recovery and Rehabilitation Unit Azienda Ospedaliera Universitaria Integrata di Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Dalle Carbonare","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200218666171031145419"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2012.08.023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2021.08.006"},{"key":"e_1_2_9_5_1","unstructured":"L. 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