{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:06:17Z","timestamp":1764313577314,"version":"3.46.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006603","name":"Bundesministerium f\u00fcr Bildung und Frauen","doi-asserted-by":"publisher","award":["01GI0914"],"award-info":[{"award-number":["01GI0914"]}],"id":[{"id":"10.13039\/501100006603","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myelin oligodendrocyte glycoprotein antibody\u2010associated disease can manifest as a relapsing or monophasic condition. Although several MRI studies have shown evident gray and white matter atrophy compared to healthy controls, little is known about regional brain volume dynamics in myelin oligodendrocyte glycoprotein antibody\u2010associated disease over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, we performed an explorative voxel\u2010based morphometry to detect brain volumetric differences between myelin oligodendrocyte glycoprotein antibody\u2010associated disease (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200927), relapsing multiple sclerosis (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200940)\u2014both in early disease stages\u2014and healthy controls (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200945). Furthermore, we investigated the longitudinal brain volume changes over a 2\u2010year follow\u2010up period in myelin oligodendrocyte glycoprotein antibody\u2010associated disease (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200915) and relapsing multiple sclerosis (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200940).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified distinct patterns of regional brain volume loss in the patient subgroups compared to healthy controls. In multiple sclerosis patients, bilateral thalamic atrophy was observed, whereas patients with myelin oligodendrocyte glycoprotein antibody\u2010associated disease showed atrophy of the bilateral fornix and stria terminalis. Our results confirmed longitudinal volume loss in thalamic and infratentorial regions in the relapsing multiple sclerosis group, which was partly related to clinical relapses during the 2\u2010year follow\u2010up period. In contrast, no longitudinal gray or white matter changes were found in the myelin oligodendrocyte glycoprotein antibody\u2010associated disease group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>To our knowledge, this is the first MRI study demonstrating no evidence of regional brain volume loss over time in patients with myelin oligodendrocyte glycoprotein antibody\u2010associated disease using voxel\u2010based morphometry, suggesting a different\u2014probably not progressive\u2014pathophysiological background compared to relapsing multiple sclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70354","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:00:51Z","timestamp":1763535651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Brain Atrophy Patterns in Early\n                    <scp>MOG<\/scp>\n                    \u2010Antibody Associated Disease and Relapsing Multiple Sclerosis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1735-4130","authenticated-orcid":false,"given":"Theodoros","family":"Ladopoulos","sequence":"first","affiliation":[{"name":"Department of Neurology St Josef Hospital, Ruhr University Bochum  Bochum Germany"},{"name":"Institute for Neuroradiology St Josef Hospital, Ruhr University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bratek","sequence":"additional","affiliation":[{"name":"Department of 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