{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:56:48Z","timestamp":1777388208365,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Myelin oligodendrocyte glycoprotein immunoglobulin G (MOG\u2010IgG) positivity has been reported in some people with multiple sclerosis (pwMS), posing a diagnostic challenge. However, most studies have been conducted in predominantly Caucasian populations. We aimed to determine the frequency of MOG\u2010IgG in a large, predominantly Asian MS cohort using a validated MOG\u2010IgG assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2005 and 2024, consecutive people diagnosed with MS according to the 2017 McDonald criteria were enrolled from the National Cancer Center registry. Serum samples from 405 pwMS were tested for MOG\u2010IgG using an in\u2010house live cell\u2010based assay at a 1:20 dilution. Borderline or positive samples were retested at a 1:100 dilution by investigators blinded to clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 405 pwMS (98% Asian, 66% female, median age at onset 28\u2009years), the overall proportion of MOG\u2010IgG positive or borderline results was 1.5% (<jats:italic>n<\/jats:italic>\u2009=\u20096). Clear MOG\u2010IgG positivity was extremely rare (<jats:italic>n<\/jats:italic>\u2009=\u20091, 0.3%), though positive or borderline results at low titer only were observed in 1.2% (<jats:italic>n<\/jats:italic>\u2009=\u20095) of pwMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>True MOG\u2010IgG positivity in MS is uncommon across populations, but low titer positive or borderline results may complicate diagnosis. Comprehensive clinical assessment remains essential, and repeat testing at higher dilutions can be helpful to avoid misdiagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.70356","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T11:09:02Z","timestamp":1757070542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>MOG<\/scp>\u2010<scp>IgG<\/scp> Frequency in Multiple Sclerosis: Diagnostic Challenges With Low\u2010Titer Results"],"prefix":"10.1111","volume":"32","author":[{"given":"Jae\u2010Won","family":"Hyun","sequence":"first","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7112-5957","authenticated-orcid":false,"given":"Rosah May Palermo","family":"Payumo","sequence":"additional","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-1323","authenticated-orcid":false,"given":"You\u2010Ri","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"},{"name":"Chon\u2010Nam University Hospital  Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Research Institute and Hospital of National Cancer Center  Goyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00431-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.0912"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/20552173211022767"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f88191"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1260358"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1108-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000649"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26793"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101939"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2024.123041"}],"container-title":["European 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Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T07:44:33Z","timestamp":1759131873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/ene.70356"],"URL":"https:\/\/doi.org\/10.1111\/ene.70356","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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