{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:48Z","timestamp":1791388128725,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The definition of conduction block (CB) is variable in multifocal motor neuropathy (MMN). In current criteria, excessive temporal dispersion (TD) may preclude the recognition of CB and the diagnosis of MMN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied the electrophysiological data of 47 consecutive subjects with MMN and of 69 consecutive controls with upper limb\u2010onset motor neuron disease, from three neuromuscular centres in the United Kingdom and Korea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to CB defined by compound muscle action potential (CMAP) area reduction (CB\u2010Area) &gt;\u200930%, CB defined by CMAP amplitude reduction (CB\u2010amp) &gt;\u200930% was more sensitive (78.7% vs. 63.8%; McNemar's Test:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), but less specific versus controls (90.1% vs. 96.7%; McNemar's Test:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). CB\u2010amp\u2009&gt;\u200930% offered greater diagnostic accuracy than CB\u2010Area\u2009&gt;\u200930% (Youden's Index: 0.688 vs. 0.606). TD showed a sensitivity of 59.6% and specificity of 94.3%. F\u2010wave prolongation or absence showed a sensitivity of 42.6% and specificity of 96.9%. Considering CB\u2010amp\u2009&gt;\u200930% or TD or F\u2010wave prolongation or absence, as independent electrodiagnostic markers of MMN, improved diagnostic sensitivity from 78.7% to 91.5% compared to CB\u2010amp\u2009&gt;\u200930% alone (McNemar's Test:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031), also offering optimal accuracy (Youden's Index: 0.816). Within this three\u2010parameter combination, CB defined by CMAP amplitude reduction &gt;\u200930% offered similar sensitivity, specificity and accuracy to when defined by CMAP amplitude reduction &gt;\u200950%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CB\u2010amp has higher sensitivity and accuracy than CB\u2010Area for the electrodiagnosis of MMN. Consideration of TD or F\u2010wave prolongation or absence, as independently diagnostic of MMN, in addition to CB\u2010amp &gt;\u200930% alone, may improve electrophysiological sensitivity as well as accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70361","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T18:08:52Z","timestamp":1759428532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Variably Defined Conduction Block, Temporal Dispersion and Other Electrophysiological Abnormalities in Multifocal Motor Neuropathy: A Multicentre Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7170-8343","authenticated-orcid":false,"given":"Yusuf A.","family":"Rajabally","sequence":"first","affiliation":[{"name":"Aston Medical School Aston University  Birmingham UK"},{"name":"Inflammatory Neuropathy Clinic, Department of Neurology University Hospitals Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-5997","authenticated-orcid":false,"given":"Young Gi","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Neurology, Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Al\u2010Areed","sequence":"additional","affiliation":[{"name":"Wessex Neurological Centre University Hospital Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-1956","authenticated-orcid":false,"given":"Woohee","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chung\u2010Ang University Hospital Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramamurthy","family":"Arunachalam","sequence":"additional","affiliation":[{"name":"Wessex Neurological Centre University Hospital Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Joon","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8245-0942","authenticated-orcid":false,"given":"Chinar","family":"Osman","sequence":"additional","affiliation":[{"name":"Wessex Neurological Centre University Hospital Southampton  Southampton 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