{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:06:18Z","timestamp":1764313578662,"version":"3.46.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We compared the prognostic value of serum neurofilament light chain (sNFL) and glial fibrillary acidic protein (sGFAP) for clinical and radiologic disease activity among patients with clinically isolated syndrome or early multiple sclerosis (MS) with optic neuritis (pwON) and non\u2010optic neuritis (pwNON) as the first manifestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients within 7\u2009months (pwON and pwNON) from disease onset and patients with MS with a disease duration longer than 12\u2009months (pwMS) as controls were included. sNFL and sGFAP were analyzed at baseline and at follow\u2010ups using SIMOA technology. Linear mixed models and Cox regression analyses were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 165 samples of 86 patients (18 pwON, 46 pwNON, 21 pwMS). Median follow\u2010up time was 80\u2009months. Mean sNFL\n                      <jats:italic>z<\/jats:italic>\n                      scores were higher in pwNON (1.06) than pwON (0.53) and pwMS (0.94). In pwNON, but not pwON, higher sNFL\n                      <jats:italic>z<\/jats:italic>\n                      scores were associated with an elevated risk for a subsequent attack (pwNON: HR 1.63 [95% CI 1.12 to 2.27],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005; pwON: HR 0.80 [95% CI 0.51\u20132.27],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.318) and new MRI T2 lesions (pwNON: HR 1.66 [95% CI 1.31 to 2.11],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; pwON: HR 1.16 [95% CI 0.82 to 1.63],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.404). sGFAP\n                      <jats:italic>z<\/jats:italic>\n                      scores were associated with a lower risk of a subsequent attack in pwON (HR 0.34 [95% CI 0.12 to 0.98],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>sNFL but not sGFAP predicted future clinical and MRI disease activity only in pwNON, potentially suggesting that the prognostic value of sNFL may depend on the type of the first manifestation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70375","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T11:55:36Z","timestamp":1762948536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Neurofilament Light Is Associated With Future Disease Activity in Clinically Isolated Syndrome and Early Multiple Sclerosis Only After Non\u2010Optic Neuritis Onset"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0058-2365","authenticated-orcid":false,"given":"Philipp","family":"Klyscz","sequence":"first","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association and Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klemens","family":"Ruprecht","sequence":"additional","affiliation":[{"name":"Division of Neuroimmunology, Department of Neurology University of Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Carlotta","family":"Anderhalten","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association and Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-5937","authenticated-orcid":false,"given":"Tanja","family":"Schmitz\u2010H\u00fcbsch","sequence":"additional","affiliation":[{"name":"Neuroscience Clinical Research Center (NCRC), Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kuhle","sequence":"additional","affiliation":[{"name":"MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Neurology, Departments of Clinical Research and Biomedicine University Hospital Basel, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Usnich","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association and Charit\u00e9 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Bellmann\u2010Strobl","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center, a Cooperation Between Max Delbr\u00fcck Center 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