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Erenumab, a monoclonal antibody targeting the calcitonin gene\u2010related peptide receptor, effectively reduces migraine frequency, but its impact on psychiatric symptoms remains unclear. This study evaluated the effects of erenumab on anxiety, depression, and sleep quality in individuals with migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This non\u2010randomized, single\u2010arm, open\u2010label trial was conducted within the prospective Registry for Migraine (REFORM). Adults with migraine received 140\u2010mg erenumab monthly for 24\u2009weeks. Anxiety, depression, and sleep\u2010related symptoms were evaluated at baseline, Week 12, and Week 24 using the hospital anxiety and depression scale (HADS) and the Pittsburgh sleep quality index (PSQI). Participants were stratified by treatment response during Weeks 13\u201324 (\u2265\u200950% reduction in monthly migraine days) and psychiatric history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 675 participants completing \u2265\u200912\u2009weeks, the proportion at risk for anxiety decreased from 30.1% (196\/651) at baseline to 22.8% (136\/597) at Week 24, and for depression from 24.9% (162\/651) to 18.3% (109\/597, both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Poor sleep quality decreased from 66.1% (429\/649) to 56.3% (333\/592,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Only \u2265\u200950% responders (300\/582, 51.5%) achieved significant improvements in anxiety, depression, and sleep\u2010related symptoms (All\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas &lt;\u200950% responders did not improve significantly (All\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Improvements were significant in both subgroups with and without psychiatric history (All\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Erenumab treatment is associated with improvement in anxiety, depression, and sleep\u2010related symptoms, specifically in treatment responders. These benefits appear mediated by migraine control rather than direct pharmacological effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70402","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:37:57Z","timestamp":1762522677000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Erenumab on Comorbid Depression, Anxiety, and Sleep Quality in Migraine: A Registry for Migraine (REFORM) Study"],"prefix":"10.1111","volume":"32","author":[{"given":"Bianca","family":"Raffaelli","sequence":"first","affiliation":[{"name":"Department of Neurology, Danish Headache Center Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Neurology, Headache Center Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Zu Berlin  Berlin 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