{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:39:18Z","timestamp":1791229158949,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We investigated whether diffusion tensor imaging (DTI) and atlas\u2010based volumetry (ABV) could track specific patterns of brain white matter (WM) microstructure and gray matter (GM) volumes in behavioral variant frontotemporal dementia (bvFTD) and amyotrophic lateral sclerosis with frontotemporal dementia (ALS\u2010FTD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MRI datasets from 65 bvFTD (including 19 with longitudinal MRI), 18ALS\u2010FTD, and 39 controls were analyzed. White matter fractional anisotropy (FA) differences were assessed using unbiased Whole Brain\u2010based Spatial Statistics (WBSS) and a hypothesis\u2010driven complementary approach consisting of Tract\u2010Wise FA Statistics (TFAS) in Tracts of Interest (TOIs) and ABV in Structures of Interest (SOIs). FA maps were correlated with disease severity (FTLD\u2010CDR sum of boxes). A random forest algorithm classified participants employing TOI and SOI data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, both bvFTD and ALS\u2010FTD exhibited WM changes in several tracts including the uncinate fasciculi, tracts originating in the corpus callosum, and the inferior and superior longitudinal fasciculi. Atrophy was most pronounced in the frontal lobes and caudate nuclei. Longitudinally, bvFTD demonstrated an antero\u2010posterior spread of WM degeneration, particularly along the corpus callosum and inferior longitudinal fasciculus, with relatively modest cortical atrophy progression. Random forest analysis identified the most discriminative TOIs and SOIs including the uncinate fasciculus and the amygdala.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate a similar pattern of structural and microstructural changes in bvFTD and ALS\u2010FTD, with a specific involvement of the corticospinal tract for ALS\u2010FTD, and support the utility of combined DTI and ABV in tracking disease progression across the FTLD spectrum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70438","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T19:44:56Z","timestamp":1764531896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>MRI<\/scp>\n                    \u2010\n                    <scp>DTI<\/scp>\n                    Biomarkers Along the Continuum of Behavioral Variant Frontotemporal Dementia"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4308-8456","authenticated-orcid":false,"given":"Marco","family":"Michelutti","sequence":"first","affiliation":[{"name":"Neurology Unit, Department of Medical, Surgical and Health Sciences University of Trieste  Trieste Italy"},{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"},{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari Aldo Moro at Pia Fondazione \u201cCard. G. Panico\u201d  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010J\u00fcrgen","family":"Huppertz","sequence":"additional","affiliation":[{"name":"Swiss Epilepsy Clinic Klinik Lengg  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Anderl\u2010Straub","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Volkmann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4503-0110","authenticated-orcid":false,"given":"Daniele","family":"Urso","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari Aldo Moro at Pia Fondazione \u201cCard. G. Panico\u201d  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Tafuri","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari Aldo Moro at Pia Fondazione \u201cCard. G. Panico\u201d  Tricase Italy"},{"name":"Department of Engineering of Innovation University of Salento  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Nigro","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari Aldo Moro at Pia Fondazione \u201cCard. G. Panico\u201d  Tricase Italy"},{"name":"Institute of Nanotechnology National Research Council (CNR\u2010NANOTEC) c\/o Campus Ecotekne  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Manganotti","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Medical, Surgical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-0338","authenticated-orcid":false,"given":"Angela","family":"Rosenbohm","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Ludolph","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Halle Martin Luther University  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0423-3242","authenticated-orcid":false,"given":"Giancarlo","family":"Logroscino","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases and the Aging Brain University of Bari Aldo Moro at Pia Fondazione \u201cCard. G. Panico\u201d  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-9381","authenticated-orcid":false,"given":"Hans\u2010Peter","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"},{"name":"Department of Diagnostic and Interventional Radiology University Hospital Ulm  Ulm Germany"},{"name":"Department of Nuclear Medicine University Hospital Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-9270","authenticated-orcid":false,"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ulm  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010023\u201000447\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWR179"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ENE.14393"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2016.1267768"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013123"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/JNNP\u20102017\u2010317459"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MOLMED.2016.07.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00401\u2010011\u20100845\u20108\/TABLES\/1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00401\u2010011\u20100839\u20106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWX254"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1134108"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMANEUROL.2013.6002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/JNNP\u20102016\u2010315018"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWR361"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWS004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00401\u2010011\u20100937\u20105"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHNEUROL.2008.558"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWY319"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2025.2461758"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.03.024"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2786"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNAGI.2018.00047"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWU090"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010235"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNAGI.2018.00045"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/MDS.26715"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JALZ.2014.01.001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JALZ.2019.05.013"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2012.12.005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u2010925X\u20106\u201042"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/JNNP\u20102017\u2010316365"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/JNNP\u20102015\u2010311952"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u2010925X\u201013\u2010128"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MRI.2008.07.003"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00401\u2010013\u20101238\u2010Y"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2011.653571"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2463\/MRMS.3.11"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/NIMG.2001.1037"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00415\u2010025\u201013215\u20109"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.COMPBIOMED.2024.109518"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12525\u2010021\u201000475\u20102"},{"key":"e_1_2_10_46_1","first-page":"2825","article-title":"Scikit\u2010Learn: Machine Learning in Python","volume":"12","author":"Pedregosa F.","year":"2012","journal-title":"Journal of Machine Learning Research"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PATCOG.2015.03.009"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/HBM.22468"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/CERCOR\/BHR288"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2017.09.007"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/HBM.22420"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0043993"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.24296"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWT094"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNEUR.2022.794618"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0090814"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/S40520\u2010018\u20101087\u20106"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWY288"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1089\/REJ.2007.0623"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000583"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWS001"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0B013E318268452E"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70324\u20102"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROBIOLAGING.2017.09.019"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ANA.23937"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009498"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2018.02.019"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2017.1332077"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROBIOLAGING.2006.07.010"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWR198"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/S13195\u2010020\u201000600\u2010X"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00401\u2010011\u20100907\u2010Y"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2023.103505"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JALZ.2015.06.724"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2010.12.008"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2012.03.072"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.221"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2024.103633"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70438","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:03:56Z","timestamp":1771401836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":77,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/ene.70438"],"URL":"https:\/\/doi.org\/10.1111\/ene.70438","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,30]]},"assertion":[{"value":"2025-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70438"}}