{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:36:09Z","timestamp":1773160569562,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insurance data allow insights into dispensations of medications. This retrospective study over 49\u2009months examined dispensations of monoclonal antibodies against calcitonin gene\u2010related peptide (CGRP\u2010mAbs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using nationwide insurance data, we examined dispensations of erenumab, fremanezumab, or galcanezumab from September 1, 2018 to September 30, 2022. We examined the duration of treatment and breaks (Kaplan\u2013Meier curves, medians, quartiles), persistence (proportion of days covered), and switches, acute medications, and other preventatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 8.8 million persons, 8934 were at least once dispensed a CGRP\u2010mAb (83.5% women, median age 45\u2009years). Median individual follow\u2010up time was 710\u2009days, median duration of treatment with any CGRP\u2010mAb was 297\u2009days, 42.9% had CGRP\u2010mAbs for at least 1\u2009year. Median duration of treatment with the first\u2010ever CGRP\u2010mAb was 327\u2009days; 63.4% experienced a therapy break. Within 1\u2009year after stopping, 53.5% resumed the same CGRP\u2010mAb, 16.9% another CGRP\u2010mAb, 29.6% did not resume any CGRP\u2010mAb; 13.7% started a second CGRP\u2010mAb and 1.7% a third. 22% definitively stopped therapy within their follow\u2010up. Dispensation of triptans decreased during and after therapy with CGRP\u2010mAbs; dispensation of other acute prescription medications was low without change. 11.4% had other preventatives before and 2.4% during CGRP\u2010mAb therapy. The proportion of days covered was 96%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this nationwide study persistence with CGRP\u2010mAbs was excellent; dispensations of triptans and other preventatives decreased during CGRP\u2010mAb therapy. Therapy breaks were common, but the majority resumed CGRP\u2010mAbs, which indicates the need for long\u2010term prophylaxis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70440","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:57:50Z","timestamp":1764842270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prescription of Monoclonal Antibodies Against Calcitonin Gene\u2010Related Peptide for the Prophylaxis of Migraine in Austria: A Retrospective, Longitudinal Analysis of Nationwide Insurance Data"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-019X","authenticated-orcid":false,"given":"Karin","family":"Zebenholzer","sequence":"first","affiliation":[{"name":"Department of Neurology, Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Gleiss","sequence":"additional","affiliation":[{"name":"Center for Medical Data Science, Institute of Clinical Biometrics Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Reichardt","sequence":"additional","affiliation":[{"name":"Austrian Social Health Insurance Fund  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Gall","sequence":"additional","affiliation":[{"name":"Center for Medical Data Science, Institute of Medical Information Management Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"W\u00f6ber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2014.20.1.22"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705848"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1212"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.4853"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420905132"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009169"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709038"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30083-2"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006640"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32534-0"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30279-9"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31946-4"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13970"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14097"},{"issue":"20","key":"e_1_2_12_16_1","first-page":"e2309","article-title":"Erenumab in Chronic Migraine With Medication Overuse: Subgroup Analysis of a Randomized Trial","volume":"91","author":"Tepper S. 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