{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:29:56Z","timestamp":1790735396276,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Aphasia after acute stroke is a frequent and disabling condition, impairing communication and quality of life. We investigated whether tablet\u2010assisted Speech and Language Therapy (\n SLT<\/jats:styled-content>\n ) using the Neolexon application is superior to standard\n SLT<\/jats:styled-content>\n in acute stroke patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective, open\u2010label, randomized, controlled clinical trial, patients with acute post\u2010stroke aphasia were recruited from one stroke center and two neurorehabilitation clinics in Germany. Participants were stratified by aphasia severity and randomized to tablet\u2010assisted\n SLT<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u2009=\u200953) or standard\n SLT<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u2009=\u200951), initiated during inpatient care and continued in rehabilitation (30\u2009min\/Day). The primary outcome was the change in the Bielefelder Aphasia Screening (\n BIAS<\/jats:styled-content>\n ) percentile rank from baseline to 90\u2009days. Secondary outcomes included frequency and duration of self\u2010training.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n From 07\/2021 to 09\/2024, 4097 patients were screened and 104 randomized (mean age 74.4\u2009\u00b1\u200911.2\u2009years; 51.9% female). No significant difference in\n BIAS<\/jats:styled-content>\n change was found at 90\u2009days (18 vs. 14). The trial was stopped early for futility. The intervention group engaged in self\u2010directed training more frequently (37.7% vs. 21.6%) and trained longer (10 vs. 4\u2009h). Subgroup analyses showed benefits of tablet\u2010assisted\n SLT<\/jats:styled-content>\n in patients with mild (\n \u03b2<\/jats:italic>\n \u2009=\u200915.51; 95%\n CI<\/jats:styled-content>\n \u22121.67 to 32.69) and moderate aphasia (\n \u03b2<\/jats:italic>\n \u2009=\u200923.58; 95%\n CI<\/jats:styled-content>\n \u22124.48 to 51.65), and those with a National Institutes of Health Stroke Scale of less than 5 (\n \u03b2<\/jats:italic>\n \u2009=\u200921.69; 95%\n CI<\/jats:styled-content>\n 5.54\u201337.84).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although underpowered to demonstrate overall superiority, tablet\u2010assisted\n SLT<\/jats:styled-content>\n showed potential benefits in patients with mild to moderate aphasia and less severe strokes in the acute setting.\n <\/jats:p>\n \n Trial Registration:<\/jats:bold>\n ClinicalTrials.gov Identifier: NCT04080817\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ene.70443","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:15:14Z","timestamp":1764166514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tablet\u2010Assisted Speech and Language Therapy for Acute\u00a0Post\u2010Stroke Aphasia: A Randomized Clinical Trial (\n LEXI<\/scp>\n Study)"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0653-943X","authenticated-orcid":false,"given":"Johannes","family":"Wischmann","sequence":"first","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanna","family":"Brasch","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Franzen","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Schwierz","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Kovalenko","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich Munich Germany"},{"name":"Department of Anaesthesiology LMU University Hospital Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Erbert","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Bu\u00dfmann","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Lauer","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Dumberger","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Mandl","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Mehringer","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"M\u00fcnsterer","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Winterhalter","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Rheinwald","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"},{"name":"Department of Orthopedics and Trauma Surgery Musculoskeletal University Center Munich (MUM), LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Lehner","sequence":"additional","affiliation":[{"name":"Institute for Social Sciences and Humanities Ostbayerische Technische Hochschule OTH Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Ammer","sequence":"additional","affiliation":[{"name":"Clinic for Neurology Medical Park, Reithof Park Bad Feilnbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Pfahler","sequence":"additional","affiliation":[{"name":"Clinic for Neurology Medical Park, Reithof Park Bad Feilnbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Lampart","sequence":"additional","affiliation":[{"name":"Clinic for Neurology Medical Park, Reithof Park Bad Feilnbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Young","sequence":"additional","affiliation":[{"name":"Clinic for Neurology Medical Park, Reithof Park Bad Feilnbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Young","sequence":"additional","affiliation":[{"name":"Clinic for Neurology Medical Park, Reithof Park Bad Feilnbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Goettert","sequence":"additional","affiliation":[{"name":"Rehabilitation Center, Passauer Wolf Bad Griesbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Bitzan","sequence":"additional","affiliation":[{"name":"Rehabilitation Center, Passauer Wolf Bad Griesbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Rinder","sequence":"additional","affiliation":[{"name":"Rehabilitation Center, Passauer Wolf Bad Griesbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Meier","sequence":"additional","affiliation":[{"name":"Rehabilitation Center, Passauer Wolf Bad Griesbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4566-712X","authenticated-orcid":false,"given":"Katharina","family":"Feil","sequence":"additional","affiliation":[{"name":"Department of Neurology & Stroke Eberhard\u2010Karls University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Hertie Institute for Clinical Brain Research Eberhard\u2010Karls University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"University Hospital Ulm (UKU) Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4967-8336","authenticated-orcid":false,"given":"Lars","family":"Kellert","sequence":"additional","affiliation":[{"name":"Department of Neurology LMU University Hospital Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.09.020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088671"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/02687038.2016.1218436"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1310\/tsr1606\u2010437"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000425.pub4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(17)30067\u22123"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.121.035216"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930221097477"},{"key":"e_1_2_11_10_1","first-page":"211","article-title":"Effect of Computer Therapy in Aphasia: A Systematic Review","volume":"30","author":"Zheng C.","year":"2015","journal-title":"Aphasiology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2017.01.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1310\/tsr1906\u2010523"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092\u20104388(2008\/018)"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200096"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0266462313000421"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/17549507.2014.887777"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.112.650671"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445778"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028\u20103932(71)90067\u20104"},{"key":"e_1_2_11_20_1","first-page":"1","article-title":"BIAS A&R: Bielefelder Aphasie Screening Akut und Reha","volume":"1","author":"Richter K.","year":"2018","journal-title":"Zur Diagnostik Akuter Und Postakuter Aphasien"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803390490918273"},{"issue":"8","key":"e_1_2_11_22_1","first-page":"473","article-title":"The Aachen Aphasia Bedside Test\u2014Criteria for Validity of Psychologic Tests","volume":"63","author":"Biniek R.","year":"1992","journal-title":"Nervenarzt. Der Aachener Aphasie\u2010Bedside\u2010Test\u2014Testpsychologische G\u00fctekriterien"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2018.05.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118625392.wbecp261"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010011\u20109903\u2010x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00294"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/24754269.2017.1398000"},{"key":"e_1_2_11_28_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1460\u20106984.12024"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00595"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(19)30192\u20109"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2021.106158"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2017.1300949"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.07.010"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta24190"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.120.031162"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1044\/2018_jslhr\u2010l\u201018\u20100254"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1044\/2025_AJSLP\u221224\u201000471"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70443","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:03:45Z","timestamp":1771401825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/ene.70443"],"URL":"https:\/\/doi.org\/10.1111\/ene.70443","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"2025-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70443"}}