{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:09:02Z","timestamp":1785179342522,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ICMR\/22\/3356\/SGP\u20102024"],"award-info":[{"award-number":["ICMR\/22\/3356\/SGP\u20102024"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammation is increasingly recognized in the pathogenesis of diabetic neuropathy (DN). Circulating miR\u201027a\u20103p levels are closely related to inflammation and increased in patients with diabetic nephropathy and retinopathy. miR\u201027a\u20103p has a predicted binding site in the 3 UTR of Netrin\u20101 mRNA, an anti\u2010inflammatory nerve growth factor whose levels correlate with small nerve fiber loss in patients with DN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty\u2010two participants with (DN+) and without (DN\u2010) small nerve fiber damage and 45 healthy controls underwent measurement of plasma miR\u201027a\u20103p, PBMC levels of NF\u2010kB and NLRP3, serum Netrin\u20101, TNF\u03b1, IL\u20101\u03b2, and IL\u201010 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Corneal nerve fiber density (CNFD), branch density (CNBD), and fiber length (CNFL) were significantly lower in the DN\u2010 and DN+ groups compared to controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Plasma miR\u201027a\u20103p and PBMC NF\u2010kB and NLRP3 expression were significantly higher in the DN+ group, and miR\u201027a\u20103p identified DN+ with an area under the curve (AUC) of 89%. Serum Netrin\u20101 and IL\u201010 levels were lower, while TNF\u03b1 and IL\u20101\u03b2 levels were higher in the DN+ group. miR\u201027a\u20103p levels correlated negatively with CNFL and Netrin\u20101 and positively with NF\u2010kB and NLRP3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>miR\u201027a\u20103p levels are elevated in subjects with DN and correlate with markers of inflammation, Netrin\u20101, and corneal nerve loss. miR\u201027a\u20103p could be a biomarker for DN, and miR\u201027a\u20103p\/Netrin\u20101 crosstalk may be a promising therapeutic target for DN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70449","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:47:04Z","timestamp":1765007224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>miR<\/scp>\n                    \u201027a\u20103p Upregulation and Netrin\u20101 Deficiency Drive Inflammatory Responses and Nerve Degeneration in Patients With Diabetes"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-0333","authenticated-orcid":false,"given":"Asif","family":"Mondal","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Institute of Post Graduate Medical Education &amp; Research (IPGME&amp;R)  Kolkata 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