{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T20:05:11Z","timestamp":1785614711605,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Distinguishing between distal myopathies (DMs) and distal hereditary motor neuropathies (dHMNs) can be challenging because clinical, EMG and biopsy findings sometimes overlap. This study aims to identify distinctive muscle MRI features that can guide the diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected clinical, genetic and muscle MRI data from patients with a confirmed diagnosis of DM and dHMN. We analyzed potential MRI characteristics to distinguish these conditions and to guide molecular diagnosis, such as the texture and pattern of infiltration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010eight (71.5%) patients diagnosed with DMs and thirty\u2010one (28.4%) with dHMNs were included. A length\u2010dependent pattern of muscle involvement, a distal to proximal gradient of fat replacement along the length of the muscles and severe and widespread involvement of foot muscles were more common in patients with dHMNs. Muscle hypertrophy and asymmetry were more frequently observed in the DMs. A reticular pattern of fat infiltration was exclusive to patients with dHMNs, while the moth\u2010eaten pattern predominated in DMs. Muscle islands were more commonly identified in dHMNs (54.8%) but were also observed in 32% of patients with DMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Analysis of MRI features can help distinguish between DMs and dHMNs. A reticular pattern is an early feature of dHMNs while muscle islands are identified in advanced stages and in some forms of DMs, though not specific to neurogenic conditions. We recommend including foot muscles in the MRI protocol as they show extensive involvement in most dHMNs, while in DMs their involvement correlates with greater fatty infiltration of lower leg muscles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70456","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:02:13Z","timestamp":1767866533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Muscle MRI Contributes to the Differential Diagnosis Between Distal Myopathies and Distal Hereditary Motor Neuropathies"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-7131","authenticated-orcid":false,"given":"Mar\u00eda","family":"Pay\u00e1","sequence":"first","affiliation":[{"name":"Neuromuscular Diseases Unit, Neurology Department Hospital Universitari I Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Member of the European Reference Network for Rare Neuromuscular Diseases (ERN EURO\u2010NMD)"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Castilla\u2010La Mancha (IDISCAM)  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Portela","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit, Neurology Department Hospital Universitari I Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Member of the European Reference Network for Rare Neuromuscular Diseases (ERN EURO\u2010NMD)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Sivera","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit, Neurology Department Hospital Universitari I Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Member of the European Reference Network for Rare Neuromuscular Diseases (ERN EURO\u2010NMD)"},{"name":"Neuromuscular and Ataxias Research Group Instituto de Investigaci\u00f3n Sanitaria La Fe  Valencia 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