{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:15:29Z","timestamp":1787242529340,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies on interrater agreement in MRI analysis for patients experiencing a first clinical episode suggestive of multiple sclerosis (MS) are limited and outdated. This study aimed to evaluate interrater agreement for lesion identification in the brain, optic nerve, and spinal cord, and to assess variability in applying the 2017 and 2024 McDonald criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy\u2010eight patients underwent a standardized multisequence 3 Tesla MRI of the brain, optic nerves, and spinal cord, analyzed by three readers with varying expertise. Lesions were categorized based on location according to McDonald criteria. Interrater variability was measured using Cohen's \u03ba for pairwise reader comparisons and Fleiss \u03ba for overall agreement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Interrater agreement ranged from slight to fair for total lesion count and moderate to substantial for lesion presence. The highest agreement occurred for spinal cord lesions (\u03ba\u2009=\u20090.84), periventricular T2 lesions (\u03ba\u2009=\u20090.70), and gadolinium\u2010enhancing brain lesions (\u03ba\u2009=\u20090.75). Classification agreement based on diagnostic criteria was substantial between the 2017 and 2024 McDonald criteria revisions (\u03ba\u2009=\u20090.65).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite advanced standardized imaging protocols at 3\u2009T, interrater agreement regarding lesion counts does not improve substantially. However, agreement in classifying lesions according to diagnostic criteria is consistent between the 2017 and 2024 criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70469","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:31:05Z","timestamp":1769160665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Does Interrater Variation Influence the Classification According to the Diagnostic Criteria for Multiple Sclerosis?"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2053-9623","authenticated-orcid":false,"given":"Nima","family":"Mahmoudi","sequence":"first","affiliation":[{"name":"Department of Neuroradiology Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Department of Diagnostic and Interventional Neuroradiology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Renne","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz Felix","family":"Konen","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin Fritz","family":"Jendretzky","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9102-124X","authenticated-orcid":false,"given":"Nora","family":"M\u00f6hn","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Grote\u2010Levi","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gingele","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"H\u00fcmmert","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schwenkenbecher","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover 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