{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T18:17:56Z","timestamp":1774721876882,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed at assessing the applicability of a symptom\u2010led staging system for primary progressive aphasia (PPA) based on retrospective medical records, as well as at exploring their demographic and clinical correlates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>75 PPA patients (10 semantic, 28 non\u2010fluent, 22 logopenic, and 16 mixed variants) were retrospectively staged according to the PPA Progression Planning Aid (PPA\u2010Squared) system, which stages the disease by accounting for clinical features along three axes: (1) Communication; (2) Non\u2010Verbal Thinking and Personality; (3) Personal Care and Well\u2010Being. The percentage of successfully staged patients was computed. The association between PPA\u2010Squared scores and demographic and clinical data was tested via non\u2010parametric tests. The predictive capability of PPA\u2010Squared scores towards survival was explored via a Mantel\u2010Cox test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      89.3% of patients were successfully staged based on retrospective medical records. The PPA\u2010Squared was associated with the MMSE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), ADL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021), and IADL scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a set of second\u2010level cognitive measures tapping on attention, executive functions, language, long\u2010term memory, and visuo\u2010spatial abilities (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.049). No association was found between the PPA\u2010Squared and demographic features, symptom duration, PPA phenotype, the presence of motor involvement, and survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      The PPA\u2010Squared is a feasible and clinically valid tool for staging PPA patients based on their cognitive and functional\n                      <jats:italic>status<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70472","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:52:32Z","timestamp":1766400752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Applicability and Correlates of a Symptom\u2010Led Staging System for Primary Progressive Aphasia"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8902-7733","authenticated-orcid":false,"given":"Edoardo Nicol\u00f2","family":"Aiello","sequence":"first","affiliation":[{"name":"Department of Neurology and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Moreschi","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Crispiatico","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Milano\u2010Bicocca  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Curti","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Lazzarini","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d Universit\u00e0 Degli Studi di Milano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Maranzano","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Silani","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory of Neuroscience 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