{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:54:16Z","timestamp":1785761656925,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371197"],"award-info":[{"award-number":["82371197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232049"],"award-info":[{"award-number":["7232049"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Disorders of consciousness (DoC) pose significant challenges in clinical diagnosis and treatment. This study aims to investigate the relationship between consciousness levels and the brainstem\u2010cortical white matter tracts in DoC patients resulting from focal brainstem injury using diffusion tensor imaging (DTI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>DTI data of DoC patients with focal brainstem injury and healthy volunteers were retrospectively collected. White matter tractography was performed to reconstruct brainstem\u2010cortical projections. The number of streamlines, total volume, and fractional anisotropy (FA) were analyzed from the perspective of global brain, physiological pathways, and functional networks. The relationship between these measurements and consciousness levels was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A cohort of 28 DoC patients and 32 healthy controls were included in the analysis. DoC patients exhibited significant reductions in the number of streamlines in global brainstem\u2010cortical projections compared to controls. However, the total volume and FA of these fibers were relatively preserved. Specific pathways such as the corticospinal tract and frontoparietal tract showed marked reductions in streamline counts. Significant reductions in streamline counts were also observed in the somatomotor and frontoparietal networks. No significant changes in mean FA were observed across different physiological pathways and brain networks. Correlation analyses revealed significant associations between consciousness levels and structural connections in the frontoparietal tract and frontoparietal network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the impact of focal brainstem injury on global brain structural connectivity in DoC patients. Despite significant reductions in streamline counts, the preservation of FA suggests maintained microstructural integrity in surviving fibers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70476","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T12:46:01Z","timestamp":1767098761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Global White Matter Damage in Focal Brainstem Injury Patients With Disorders of Consciousness: A Diffusion Tensor Tractography Study"],"prefix":"10.1111","volume":"33","author":[{"given":"Miao","family":"Wang","sequence":"first","affiliation":[{"name":"Academy for Advanced Interdisciplinary Studies Peking University  Beijing China"},{"name":"IDG\/McGovern Institute for Brain Research Peking University  Beijing China"},{"name":"Peking\u2010Tsinghua Center for Life Sciences Peking University  Beijing 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