{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:45:23Z","timestamp":1778899523042,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia surface receptor that aids in tissue repair and debris clearance. The soluble form, sTREM2, found in both blood and cerebrospinal fluid, is considered a biomarker for microglial activation. Based on the central role of microglia in MS pathogenesis, we aimed to investigate whether serum sTREM2 levels could predict disability progression in patients with primary progressive MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum levels of sTREM2 were measured at baseline using a single\u2010molecule array assay in a multicenter cohort of 137 primary progressive multiple sclerosis (PPMS) patients. Univariable and multivariable linear models evaluated the association between sTREM2 levels and EDSS change at 2\u2009years, 6\u2009years, and last follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While an association was observed at 2\u2009years only in non\u2010inflammatory PPMS patients, no consistent relationship was found between sTREM2 levels and disability progression over longer follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that serum sTREM2 may have limited value as a biomarker of disability progression in PPMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70480","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:42:42Z","timestamp":1769773362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum\n                    <scp>sTREM2<\/scp>\n                    Levels and Disability Progression in Patients With Primary Progressive Multiple Sclerosis"],"prefix":"10.1111","volume":"33","author":[{"given":"Nicol\u00e1s","family":"Fissolo","sequence":"first","affiliation":[{"name":"Servei de Neurologia, Centre D'esclerosi M\u00faltiple de Catalunya (Cemcat) Institut de Recerca Vall D'hebron (VHIR), Hospital Universitari Vall D'hebron. Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED) \u2013 ISCIII  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Benkert","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Clinical Research, Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB) University Hospital and University of Basel  Basel Switzerland"},{"name":"Department of Neurology University Hospital and University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreu","family":"Vilaseca\u2010Jolonch","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre D'esclerosi M\u00faltiple de Catalunya (Cemcat) Institut de Recerca Vall D'hebron (VHIR), Hospital Universitari Vall D'hebron. Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Blanco","sequence":"additional","affiliation":[{"name":"Center of Neuroimmunology, Service of Neurology, Hospital Clinic Institut D'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2833-6337","authenticated-orcid":false,"given":"Harald","family":"Hegen","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Berek","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"P\u00e9rez\u2010Miralles","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit Val\u00e8ncia University and Polytechnic Hospital La Fe  Val\u00e8ncia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Rejdak","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Villar","sequence":"additional","affiliation":[{"name":"Department of Neurology and Immunology Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigacion Sanitaria  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enric","family":"Monreal","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Ram\u00f3n y Cajal, REEM, IRYCIS, Universidad de Alcal\u00e1  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Alvarez\u2010Lafuente","sequence":"additional","affiliation":[{"name":"Environmental Factors in Degenerative Diseases Research Group, Hospital Cl\u00ednico San Carlos Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Bachhuber","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[{"name":"Department of Neurology Ulm University  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Mart\u00ednez\u2010Yelamos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Multiple Sclerosis Unit Hospital Universitari de Bellvitge  Barcelona Spain"},{"name":"Neurology and Neurogenetics Group. Neuroscience Program Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL)  Barcelona Spain"},{"name":"Department of Clinical Sciences School of Medicine, Universitat de Barcelona (UB), L'Hospitalet de Llobregat, Spain  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"S\u00e1nchez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit Puerta de Hierro\u2010Segovia de Arana Health Research Institute  Madrid Spain"},{"name":"Biobank Puerta de Hierro\u2010Segovia de Arana Health Research Institute  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Garc\u00eda\u2010Merino","sequence":"additional","affiliation":[{"name":"Neuroimmunology Unit Puerta de Hierro\u2010Segovia de Arana Health Research Institute  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre D'esclerosi M\u00faltiple de Catalunya (Cemcat) Institut de Recerca Vall D'hebron (VHIR), Hospital Universitari Vall D'hebron. Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Castillo\u2010Trivi\u00f1o","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Universitario Donostia  San Sebasti\u00e1n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lycke","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igal","family":"Rosenstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nieves","family":"T\u00e9llez","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Cl\u00ednico Universitario de Valladolid.  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-9425","authenticated-orcid":false,"given":"Roberto","family":"Furlan","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Clinical Neuroimmunology Unit Institute of Experimental Neurology, IRCCS Ospedale San Raffaele  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan D.","family":"L\u00fcnemann","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Kuhle","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Clinical Research, Multiple Sclerosis Centre and Research Center for Clinical Neuroimmunology and Neuroscience (RC2NB) University Hospital and University of Basel  Basel Switzerland"},{"name":"Department of Neurology University Hospital and University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Montalban","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre D'esclerosi M\u00faltiple de Catalunya (Cemcat) Institut de Recerca Vall D'hebron (VHIR), Hospital Universitari Vall D'hebron. Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED) \u2013 ISCIII  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Comabella","sequence":"additional","affiliation":[{"name":"Servei de Neurologia, Centre D'esclerosi M\u00faltiple de Catalunya (Cemcat) Institut de Recerca Vall D'hebron (VHIR), Hospital Universitari Vall D'hebron. Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED) \u2013 ISCIII  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105630"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636837"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040124"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn217"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12845"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/20552173211019772"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.0017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2025.106268"},{"issue":"5","key":"e_1_2_9_10_1","first-page":"410","article-title":"Serum Biomarker Levels Predict Disability Progression in Patients With Primary Progressive Multiple Sclerosis","volume":"95","author":"Fissolo N.","year":"2024","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000921"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70480","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:19:11Z","timestamp":1772993951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/ene.70480"],"URL":"https:\/\/doi.org\/10.1111\/ene.70480","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70480"}}