{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T23:55:22Z","timestamp":1769298922663,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cryptogenic strokes (CS) represent one third of admissions for stroke. Silent paroxysmal atrial fibrillation (PAF) is the underlying cause of a significant proportion of cases. The use of internal loop recorders (ILR) after CS has shown controversial results, remaining unclear in guidelines. Subtle ultrasound left atrium (LA) anomalies may help select patients more prone to suffer from silent PAF who can benefit from an ILR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized, controlled, parallel\u2010arm, open\u2010label trial of patients with CS. We evaluated the efficacy of early ILR for detection of silent PAF episodes compared to standard care. Clinical\/ultrasound predictors of PAF were studied. The presence of subtle LA anomalies (any of: LA dilatation, maximum systolic global longitudinal strain &lt;\u200921%, atrial contraction strain &lt;\u200913%, atrial ejection fraction &lt;\u200955%) was used in a pre\u2010specified subgroup analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010nine CS patients were included (52.5% to ILR and 47.5% to standard care). There were no statistically significant differences among groups regarding baseline characteristics. Median follow\u2010up was 377\u2009days. The diagnosis of silent PAF was made in 43.3% in the ILR group compared to 7.1% in the control group (HR 7.47, 95% CI 1.68\u201331.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Most PAF events were detected in the 100\u2009days following ILR implantation. In patients with normal LA, PAF was observed in 23% versus 7%, while in patients with abnormal LA, PAF was diagnosed in 58.8% versus 7.7%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An ILR implanted early after CS improves the detection of PAF compared to standard care. Individuals with abnormal LA features may benefit the most from ILR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70482","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T11:58:37Z","timestamp":1767355117000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultra\u2010Early Continuous\n                    <scp>ECG<\/scp>\n                    Monitoring for Silent Atrial Fibrillation Diagnosis in Cryptogenic Stroke: The\n                    <scp>CRIPTOFAST<\/scp>\n                    Randomized Controlled Trial"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-8274","authenticated-orcid":false,"given":"E.","family":"Vall\u00e8s","sequence":"first","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Giralt\u2010Steinhauer","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ble","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. I.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Casteigt","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E.","family":"Gonz\u00e1lez\u2010Matos","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Cuadrado\u2010Godia","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zaraket","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2746-3243","authenticated-orcid":false,"given":"O.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Guelfand","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Guijo","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cainzos\u2010Achirica","sequence":"additional","affiliation":[{"name":"Hospital del Mar and Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1503946"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873221099478"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70310-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00475-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313600"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.031508"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14061"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.816511"},{"issue":"9","key":"e_1_2_11_11_1","article-title":"A Comprehensive Review of Cryptogenic Stroke and Atrial Fibrillation: Real\u2010World Insights Into the Role of Insertable Cardiac Monitors","volume":"16","author":"Khan F.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-023-02283-4"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.14740\/cr2016"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.07.004"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12397-y"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2024.00584"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163501"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00873-2"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.101883"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-023-02218-z"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311376"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829d8773"},{"issue":"9","key":"e_1_2_11_23_1","first-page":"717","article-title":"Plasma Levels of miRNA\u20101\u20103p Are Associated With Subclinical Atrial Fibrillation in Patients With Cryptogenic Stroke","volume":"75","author":"Benito B.","year":"2022","journal-title":"Revista Espanola de Cardiologia (English ed.)"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70482","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T11:49:38Z","timestamp":1769255378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ene.70482"],"URL":"https:\/\/doi.org\/10.1111\/ene.70482","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70482"}}