{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:03:15Z","timestamp":1773003795492,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reversible cerebral vasoconstriction syndrome (RCVS) is a neurovascular disorder with unclear pathophysiology, particularly concerning systemic endothelial function. Understanding arterial stiffness could shed light on potential systemic vascular involvement in RCVS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate systemic endothelial dysfunction in patients with RCVS by assessing arterial stiffness using pulse wave velocity (PWV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, age\u2010 and sex\u2010matched, 1:1 case\u2013control study from January 2020 to January 2023 at Nantes University Hospital. Patients diagnosed with definite RCVS according to ICHD\u20103 criteria were enrolled as cases; controls were matched individuals without RCVS. All participants underwent PWV measurement as a noninvasive marker of arterial stiffness. Follow\u2010up PWV assessments were performed in RCVS patients at 1 and 3\u2009months after onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010two subjects with a mean age of 49.8\u2009years (70% female) were included. One\u2010third of RCVS cases had secondary triggers. Mean systolic and diastolic blood pressures were 130.8\u2009\u00b1\u200924.0\u2009mmHg and 80.6\u2009\u00b1\u20091.4\u2009mmHg, respectively, with 29% of patients presenting acute hypertension. No systemic organ dysfunction was observed in cardiac, renal, or hepatic assessments. PWV values at the acute stage showed no significant difference between patients and controls (7.0 vs. 6.4\u2009m.s\n                      <jats:sup>\u22121<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8701). PWV increased transiently from 7.7 to 9.2\u2009m.s\n                      <jats:sup>\u22121<\/jats:sup>\n                      at 1\u2009month but returned to 8.1\u2009m.s\n                      <jats:sup>\u22121<\/jats:sup>\n                      by 3\u2009months, without statistically significant overall changes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.5331).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic arterial stiffness, as measured by PWV, remains normal and stable throughout the course of RCVS even during the acute phase and recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , NCT04463212\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70495","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:59:09Z","timestamp":1769507949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Arterial Stiffness in Reversible Cerebral Vasoconstriction Syndrome: A Prospective Case\u2013Control Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-2816","authenticated-orcid":false,"given":"Pac\u00f4me","family":"Constant dit Beaufils","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes Service de Neurologie, CNRS, INSERM, L'institut du Thorax  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La\u00ebtitia","family":"Barbin","sequence":"additional","affiliation":[{"name":"CHU Nantes Service de Neurologie  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-1255","authenticated-orcid":false,"given":"Morgane","family":"Pere","sequence":"additional","affiliation":[{"name":"Plateforme de M\u00e9thodologie et Biostatistique, Direction de la Recherche et de l'Innovation Centre Hospitalier Universitaire de Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8784-1609","authenticated-orcid":false,"given":"Clarisse","family":"Colleu","sequence":"additional","affiliation":[{"name":"CHU Nantes Service de Neurologie  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2129-2386","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Connault","sequence":"additional","affiliation":[{"name":"CHU Nantes Department of Internal and Vascular Medicine  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3082-2689","authenticated-orcid":false,"given":"C\u00e9cile","family":"Pr\u00e9terre","sequence":"additional","affiliation":[{"name":"CHU Nantes Service de Neurologie  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7539-7263","authenticated-orcid":false,"given":"Beno\u00eet","family":"Guillon","sequence":"additional","affiliation":[{"name":"CHU Nantes Service de Neurologie  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-9589","authenticated-orcid":false,"given":"Sol\u00e8ne","family":"de Gaalon","sequence":"additional","affiliation":[{"name":"CHU Nantes Service de Neurologie  Nantes 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ICHD\u20103 The International Classification of Headache Disorders 3rd Edition \u201daccessed January 17 2021 https:\/\/ichd\u20103.org\/6\u2010headache\u2010attributed\u2010to\u2010cranial\u2010or\u2010cervical\u2010vascular\u2010disorder\/6\u20107\u2010headache\u2010attributed\u2010to\u2010other\u2010acute\u2010intracranial\u2010arterial\u2010disorder\/6\u20107\u20103\u2010headache\u2010attributed\u2010to\u2010reversible\u2010cerebral\u2010vasoconstriction\u2010syndrome\u2010rcvs\/6\u20107\u20103\u20101\u2010headache\u2010probably\u2010attributed\u2010to\u2010reversible\u2010cerebral\u2010vasoconstriction\u2010syndrome\u2010rcvs\/."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq165"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25965"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70135\u20107"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001740"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000239206.64270.5f"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872\u2010200210000\u201000001"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013136"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929\u2010022\u201000857\u20104"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3154"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010019\u201009594\u20105"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.67.3.733"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.027121"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2025.01.411"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4768"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21951"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2025.01.411"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.67.3.733"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/crnm\/3126513"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.046312"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70495","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:19:40Z","timestamp":1772993980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/ene.70495"],"URL":"https:\/\/doi.org\/10.1111\/ene.70495","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70495"}}