{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:08:27Z","timestamp":1785812907677,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R366\u20102021\u2010127"],"award-info":[{"award-number":["R366\u20102021\u2010127"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore pathological findings on magnetic resonance imaging (MRI) and their diagnostic implications in early\u2010stage neuroborreliosis (NB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Adult patients from the Danish neuroinfections cohort (DASGIB, 2015\u20132019) with confirmed NB, symptom duration &lt;\u20096\u2009months, and MRI performed within 14\u2009days of diagnosis were included. MRIs were retrospectively reinterpreted by an unblinded neuroradiologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 116 patients, 123 MRIs were performed (99 brain, 44 spine, 46 with contrast). White matter lesions (WML) were common, but non\u2010specific and associated with increasing age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Six patients showed WML not typical for small vessel disease. Acute infarctions occurred in four patients. Encephalitis was clinically diagnosed in five patients; one showed brainstem FLAIR hyperintensities. In 45 contrast\u2010enhanced brain scans, leptomeningeal enhancement was identified in 6 (13%) and cranial nerve enhancement in 29 (64%). There was poor correlation between facial palsy and enhancement. Spinal cord lesions (1.6\u201314\u2009cm) were identified in 10 of 44 scans (23%) without symptoms of transverse myelitis. Among 13 contrast\u2010enhanced spine scans, 8 showed leptomeningeal enhancement (61%), and 8 showed nerve root enhancement (61%). Most enhancements did not match symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pathological findings were found in 35 of 46 patients with contrast\u2010enhanced MRIs. Key findings included cranial nerve, spinal nerve root, and leptomeningeal enhancement\u2014often without clinical correlation. Spinal cord lesions were relatively frequent; cerebral infarction was rare. While key findings can support the diagnosis, their absence does not exclude NB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70500","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T08:55:21Z","timestamp":1770627321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Findings on Magnetic Resonance Imaging in Neuroborreliosis\u2014A Nationwide Cohort Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0737-8076","authenticated-orcid":false,"given":"Mathilde","family":"\u00d8rb\u00e6k","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital, Rigshospitalet  K\u00f8benhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitesh","family":"Shekhrajka","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Copenhagen University Hospital, Rigshospitalet  K\u00f8benhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maja M\u00f8hring","family":"Gynthersen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital, Rigshospitalet  K\u00f8benhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Bodilsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lykke","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Storgaard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aarhus University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Infectious Diseases, Nordsj\u00e6llands Hospital \u2013 Hiller\u00f8d University of Copenhagen  Hiller\u00f8d Denmark"},{"name":"Department of Infectious Diseases Zealand University Hospital \u2013 Roskilde  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Wiese","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zealand University Hospital \u2013 Roskilde  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte R\u00f8nde","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hvidovre University Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans R.","family":"Luttichau","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Herlev\u2010Gentofte Hospital  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aase Bengaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital, Rigshospitalet  K\u00f8benhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-1418","authenticated-orcid":false,"given":"Helene","family":"Mens","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital, Rigshospitalet  K\u00f8benhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-3289","authenticated-orcid":false,"given":"Anne\u2010Mette","family":"Lebech","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital, Rigshospitalet  K\u00f8benhavn Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The DASGIB Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix568"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2020.101549"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2022.0070"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux047"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60103-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.121"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.2.399"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-022-02957-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.6.753"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2020.101411"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-2112-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2024.07.004"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-018-0646-x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2300-x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117176"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10188-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa370"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2531081103"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850701367903"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.016"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02862.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980-57642015DN94000350"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12667"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.11.001"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20220108"},{"key":"e_1_2_11_29_1","volume-title":"StatPearls","author":"Sharma R.","year":"2024"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016160031"},{"key":"e_1_2_11_31_1","first-page":"892","article-title":"MR Imaging Assessment of Brain and Cervical Cord Damage in Patients With Neuroborreliosis","volume":"27","author":"Agosta F.","year":"2006","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_11_32_1","first-page":"479","article-title":"Lyme Disease of the CNS: MR Imaging Findings in 14 Cases","volume":"11","author":"Fernandez R. E.","year":"1990","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-024-03482-0"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.11.1980"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1579"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6831-4"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117544"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-63006-x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac206"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13101388"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.03.056"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00146"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000155982"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70203-X"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09387-w"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.12.034"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-020-01917-8"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-008-0581-4"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.05.002"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.10.004"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-021-00268-x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52902-2.00032-1"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70500","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:19:23Z","timestamp":1772993963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/ene.70500"],"URL":"https:\/\/doi.org\/10.1111\/ene.70500","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70500"}}