{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:54:18Z","timestamp":1791942858584,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ocrelizumab and natalizumab are highly effective disease\u2010modifying treatments for relapsing\u2013remitting multiple sclerosis (RRMS). Direct comparison of effectiveness is crucial for optimizing treatment decisions and improving patient outcomes. The aim was to compare any difference in effectiveness of ocrelizumab and natalizumab on disease activity and progression in RRMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a national multicenter comparative effectiveness research study using data from the nationwide population\u2010based registry of MS cases in Denmark. Patients were included from January 2018 to April 2023 with a history of RRMS treated with ocrelizumab or natalizumab. Inverse probability of treatment weighting based on propensity scores was applied. Main outcomes were the comparison of annualized relapse rate (ARR), time to first progression independent of relapse activity (PIRA), and time to first occurrence of new\/enlarging T2 or contrast\u2010enhancing lesions on cerebral MRI scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found no statistically significant differences in the ARR between ocrelizumab\u2010treated (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009542) and natalizumab\u2010treated (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009384) patients (mean [95% CI] ARR of 0.071 [0.057\u20130.088] and 0.071 [0.054\u20130.092], respectively) and in the ARR ratio (0.996, 95% CI [0.687\u20131.444],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.983). Similarly, we did not find differences between the two groups in terms of time to first PIRA (HR, 1.34; 95% CI, 0.88\u20132.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.17) and time to first inflammatory activity in MRI scans (HR, 1.04; 95% CI, 0.74\u20131.25;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study could not demonstrate a difference in effectiveness of ocrelizumab and natalizumab treatment in this nationwide population\u2010based registry study in risk of relapses, disability progression, and MRI activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70507","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:11:43Z","timestamp":1769602303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A National Danish Effectiveness Study of Ocrelizumab Versus Natalizumab in Multiple Sclerosis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8408-9343","authenticated-orcid":false,"given":"Camilla","family":"Maersk\u2010Moller","sequence":"first","affiliation":[{"name":"Department of Neurology Multiple Sclerosis Clinic, Aarhus University Hospital  Aarhus N Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-3827","authenticated-orcid":false,"given":"Luigi","family":"Pontieri","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Danish Multiple Sclerosis Registry Copenhagen University Hospital\u2014Rigshospitalet Glostrup  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Leif Munding","family":"Stilund","sequence":"additional","affiliation":[{"name":"Department of Neurology, Physiotherapy and Occupational Therapy G\u00f8dstrup Hospital  Herning Denmark"},{"name":"NIDO, Centre for Research and Education G\u00f8dstrup Hospital  Herning Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7727-3467","authenticated-orcid":false,"given":"Jeppe Romme","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Multiple Sclerosis Center Copenhagen University Hospital \u2013 Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Kristian","family":"Storr","sequence":"additional","affiliation":[{"name":"Department of Neurology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-1818","authenticated-orcid":false,"given":"Jakob","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Neurology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz","family":"Weglewski","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital, Herlev and Gentofte  Herlev Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina Quinto","family":"Romani","sequence":"additional","affiliation":[{"name":"Department of Neurology Viborg Hospital  Viborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-3787","authenticated-orcid":false,"given":"Henrik Boye","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Neurology Lillebaelt Hospital  Kolding Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark  Odense M Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Illes","sequence":"additional","affiliation":[{"name":"Department of Neurology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Papp","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Multiple Sclerosis 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