{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:22:20Z","timestamp":1789262540886,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3501303"],"award-info":[{"award-number":["2022YFC3501303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3501305"],"award-info":[{"award-number":["2022YFC3501305"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471426"],"award-info":[{"award-number":["82471426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Municipal Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2023CRD007"],"award-info":[{"award-number":["SHDC2023CRD007"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myasthenic crisis (MC) affects 10%\u201320% of myasthenia gravis patients and is life\u2010threatening with significant economic burden, yet its long\u2010term outcomes remain poorly understood. This prospective multicentre study aimed to evaluate 1\u2010year clinical outcomes after MC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study enrolled patients with MC between December 2018 and October 2024 and prospectively followed at 1, 2, 3, 6, and 12\u2009months post\u2010MC. Outcome measures included Myasthenia Gravis Foundation of America (MGFA) postintervention status (PIS) classification at 1\u2009year after MC, all\u2010cause mortality, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort comprised 277 patients with 282 MC episodes with a follow\u2010up duration of 29.16\u2009\u00b1\u200915.93\u2009months. The in\u2010hospital mortality was 5.05% (14\/277), while the all\u2010cause mortality was 15.16% (42\/277). The leading causes of death were septic shock (35.7%) and multiple organ failure (21.4%). Among 247 patients with complete 1\u2010year follow\u2010up, 79.76% (197\/247) achieved favorable outcomes. MG\u2010ADL scores reduced from 21.3\u2009\u00b1\u20092.1 at baseline to 5.5\u2009\u00b1\u20091.5 at 6\u2009months, and 2.8\u2009\u00b1\u20091.1 at 1\u2009year post\u2010MC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Multivariable analysis identified older age at crisis (OR 1.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), thymoma comorbidity (OR 1.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041), higher comorbidity burden (Charlson Comorbidity Index\u2009\u2265\u20093, OR 2.68,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and prolonged ICU stay (OR 1.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) as independent predictors for minimal symptom expression non\u2010responders. The most frequent chronic complications included infections (15.2%; predominantly fungal pathogens), gastrointestinal disorders (8.3%), and osteoporosis\/fractures (5.1%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first prospective cohort study to report clinical outcomes in MG patients at post\u2010MC stage, highlighting the importance of disease monitoring and early intervention to improve patient\u2010centred care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70513","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:00:53Z","timestamp":1769508053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["1\u2010Year Clinical Outcome Post\u2010Myasthenic Crisis: A Multicenter Prospective Study in China"],"prefix":"10.1111","volume":"33","author":[{"given":"Xiao","family":"Huan","sequence":"first","affiliation":[{"name":"Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Chen","sequence":"additional","affiliation":[{"name":"Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders Fudan University  Shanghai 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Neurosurgery &amp; Neurocritical Care, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1471-9078","authenticated-orcid":false,"given":"Jianming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, National Medical Center for Infectious Diseases Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhan no. 1 Hospital  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First People's Hospital of Changzhou, Third Affiliated Hospital of Soochow University  Changzhou 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Renji Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Army Medical Center of PLA Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoxian","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neurology Qilu Hospital (Qingdao), Shandong University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarong","family":"Li","sequence":"additional","affiliation":[{"name":"Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders Fudan University  Shanghai China"},{"name":"Institute of Neurology, Huashan Hospital Fudan University  Shanghai 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