{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:03:22Z","timestamp":1773003802049,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hemiplegic migraine (HM) is a rare subtype of migraine with aura, characterized by transient, unilateral motor weakness. Due to its rarity, treatment strategies are lacking. Monoclonal antibodies targeting the calcitonin gene\u2010related peptide (CGRP) pathway have emerged as a potential therapeutic option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 64\u2010year\u2010old man was admitted to an Austrian stroke unit with acute aphasia, right\u2010sided hemiplegia, and reduced consciousness. MRI showed no ischemia or hemorrhage. Cerebrospinal fluid analysis revealed pleocytosis (146\u2009cells\/\u03bcL) without signs of infection. By Day 4, the patient showed improving hemiparesis and new\u2010onset hemicranial headache. Aphasia resolved by Day 14 and hemiparesis by Day 21. The patient's history included non\u2010Hodgkin lymphoma with cerebral relapse, treated with whole\u2010brain irradiation and stem cell transplantation in 2007, and a history of migraine with aura. Differential diagnoses such as SMART syndrome and HaNDL were considered, but the improvement of symptoms following headache onset and the prior migraine history supported the diagnosis of sporadic hemiplegic migraine (SHM). Genetic testing revealed no mutations associated with familial HM. Initial treatment with lamotrigine was followed by monthly fremanezumab (225\u2009mg). No further HM attacks occurred over 6\u2009months of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case illustrates the diagnostic complexity of SHM and adds to the growing body of anecdotal observations suggesting that CGRP monoclonal antibodies may be a promising preventive treatment for patients with HM. Further studies are needed to evaluate their efficacy in this rare migraine subtype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70514","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:15:09Z","timestamp":1769519709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced Frequency of Prolonged Sporadic Hemiplegic Migraine Attacks Following Fremanezumab Treatment\u2014A Case Report"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0270-790X","authenticated-orcid":false,"given":"Julian Frederic","family":"Hotz","sequence":"first","affiliation":[{"name":"Department of Neurology St. John of God Hospital  Vienna Austria"},{"name":"Division of Infectious Diseases and Tropical Medicine, Department of Medicine I Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Kaindl","sequence":"additional","affiliation":[{"name":"Department of Neurology St. John of God Hospital  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Krebs","sequence":"additional","affiliation":[{"name":"Department of Neurology St. John of God Hospital  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Vigl","sequence":"additional","affiliation":[{"name":"Department of Neurology St. John of God Hospital  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Neurology St. John of God Hospital  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Radiology St. John's 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