{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:03:20Z","timestamp":1773003800158,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20355"],"award-info":[{"award-number":["U20A20355"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571629"],"award-info":[{"award-number":["82571629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171256"],"award-info":[{"award-number":["82171256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the prevalence of probable REM sleep behavior disorder (pRBD) in essential tremor (ET), identify associated risk factors, and evaluate its effects on motor and non\u2010motor symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data were collected from 1297 ET patients across multicenter. pRBD was assessed using the RBD Questionnaire\u2010Hong Kong (RBDQ\u2010HK). Risk factors associated with pRBD were identified through multivariable logistic regression. Furthermore, a meta\u2010analysis was conducted to synthesize existing estimates of pRBD\/RBD prevalence in ET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, pRBD was identified in 11.6% of ET patients. Meta\u2010analysis yielded pooled prevalence estimates of 16% for pRBD (ES\u2009=\u20090.16, 95% CI [0.10\u20130.21]) and 14% for RBD (ES\u2009=\u20090.14, 95% CI [0.07\u20130.21]). ET patients with pRBD were older (59.89\u2009\u00b1\u200913.99 vs. 54.63\u2009\u00b1\u200916.59\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and had a later tremor onset (47.55\u2009\u00b1\u200915.98 vs. 43.15\u2009\u00b1\u200917.62\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) compared with those without pRBD. ET\u2010pRBD patients also exhibited a higher frequency of midline tremor (54.67% vs. 43.93%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), rest tremor (27.33% vs. 16.04%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and elevated Non\u2010Motor Symptom Scale (NMSS) scores (20.30\u2009\u00b1\u200918.50 vs. 10.43\u2009\u00b1\u200912.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariable logistic regression identified lower educational attainment (OR\u2009=\u20090.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and higher NMSS scores (OR\u2009=\u20091.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) as independent risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>pRBD is prevalent in ET and independently associated with lower education and increased non\u2010motor symptom burden. Recognition of pRBD may help identify an ET subgroup with distinctive clinical features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70516","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:01:40Z","timestamp":1770703300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Impact of Probable REM Sleep Behavior Disorder in Essential Tremor: A Multicenter Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4113-1141","authenticated-orcid":false,"given":"Yuzheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Multi\u2010Omics Research Center for Brain Disorders, The First Affiliated Hospital, Hengyang Medical School University of South China  Hengyang Hunan China"},{"name":"Department of Neurology, The Second Affiliated Hospital, Hengyang Medical 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