{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:14:09Z","timestamp":1780092849367,"version":"3.54.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder marked by mucocutaneous telangiectasias, recurrent epistaxis, and visceral arteriovenous malformations (AVMs). Neurologic risks include brain AVMs and hemorrhagic stroke. Several rare genetic and sporadic syndromes (\u201cHHT\u2010like\u201d syndromes) share overlapping vascular features, complicating diagnosis. Differentiating these conditions is essential for accurate neurovascular risk assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature review (PubMed, Scopus, Embase, Google Scholar; 1990\u20132025) targeted cerebrovascular manifestations of HHT and related syndromes. Key entities included Wyburn\u2013Mason syndrome, Cobb syndrome, Klippel\u2013Tr\u00e9naunay syndrome (KTS), neurofibromatosis type 1 (NF1), PHACE(S) syndrome, capillary malformation\u2013AVM (CM\u2010AVM), Parkes Weber syndrome (PWS), juvenile polyposis\/HHT overlap (JP\u2010HHT), HHT type 5 (BMP9\/GDF2), PTEN hamartoma tumor syndrome (PHTS), and blue rubber bleb nevus syndrome (BRBNS). Data on gene variants, lesion types, neuroimaging, stroke risk, and neurologic outcomes were synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High\u2010flow cerebrovascular malformations similar to HHT are prominent in Wyburn\u2013Mason syndrome, CM\u2010AVM, and PWS, conferring a substantial hemorrhagic stroke risk. NF1 and PHACE(S) primarily feature occlusive arteriopathies linked to ischemic events. KTS, BRBNS, and PHTS predominantly show low\u2010 or mixed\u2010flow anomalies with lower CNS hemorrhagic risk but increased thrombotic complications. JP\u2010HHT carries added gastrointestinal cancer risk via SMAD4 variants, while HHT type 5 often presents incompletely. Genetic testing and tailored neuroimaging are critical for differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although many syndromes mimic HHT, few combine mucosal telangiectasias, high\u2010flow AVMs, and recurrent hemorrhage. Integrating clinical, imaging, and genetic data enables precise diagnosis, risk stratification, and personalized management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70523","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:04:23Z","timestamp":1771405463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebrovascular Malformations Associated With Hereditary Hemorrhagic Telangiectasia and\n                    <scp>HHT<\/scp>\n                    \u2010Like Syndromes: A Comparative Overview"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0948-5750","authenticated-orcid":false,"given":"Matteo","family":"Palermo","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Fondazione Policlinico Universitario A. 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