{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:42:26Z","timestamp":1789512146322,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurocardiac autonomic impairment with reduced heart rate variability (HRV) has been linked to SARS\u2010CoV\u20102 infection and may persist in patients with post\u2010COVID\u201019 syndrome. We synthesised meta\u2010analytic data on HRV in post\u2010COVID\u201019 syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our systematic review and meta\u2010analysis were guided by PRISMA standards. We used MEDLINE, Embase and Web of Science to identify non\u2010randomised studies of HRV in patients with post\u2010COVID\u201019 syndrome, conducted more than 3\u2009months after infection and compared with healthy controls. The search covered the period from 01\/2020 to 09\/2023. We pooled data on the following HRV parameters: standard deviation of normal\u2010to\u2010normal intervals (SDNN), root mean square of successive differences (rMSSD) and low\u2010frequency to high\u2010frequency ratio (LF\/HF ratio). We applied a random effects model to account for heterogeneity. Risk of bias was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 856 initially identified records, we included 11 studies with a total of 1162 participants (593 post\u2010COVID\u201019 patients and 565 healthy controls). We observed a trend toward lower HRV in post\u2010COVID patients compared to controls, with small to medium effects for SDNN (SMD: 0.26, 95% CI: \u22120.03 to 0.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09), rMSSD (SMD: 0.11, 95% CI: \u22120.15 to 0.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.41) and LF\/HF ratio (SMD: \u20130.271, 95% CI: \u22120.61 to 0.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12). Moderate to high statistical heterogeneity of the effects was observed (I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200983% for SDNN and 78% for rMSSD) and nine of 11 studies had a high risk of bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis suggests a possible association between post\u2010COVID condition and alterations in neurocardiac autonomic function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70561","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:15:09Z","timestamp":1773292509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurocardiac Autonomic Dysfunction in Patients With Post\u2010\n                    <scp>COVID<\/scp>\n                    \u201019 Condition: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Daniela","family":"Schoene","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"},{"name":"Dresden International University  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Deckert","sequence":"additional","affiliation":[{"name":"Center for Evidence\u2010Based Healthcare, University Hospital and Faculty of Medicine Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Barlinn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden 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