{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:16:18Z","timestamp":1783433778811,"version":"3.54.6"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Radiation\u2010induced (radiculo)plexopathy [RI(R)P] is a debilitating delayed neurological adverse event occurring in cancer survivors years after the irradiation of the brachial or lumbar plexuses. No effective treatments have been identified to date. The objective of this work was to evaluate the effectiveness of the anti\u2010VEGF bevacizumab in the treatment of RI(R)P.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively identified patients diagnosed with contrast\u2010enhancing RI(R)P and treated with bevacizumab in the setting of an institutionally sponsored expanded access program over the last 10\u2009years. Clinical, radiological, and neurophysiological records were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified nine patients manifesting with neurophysiological\u2010confirmed RI(R)P (brachial plexopathy, 4; lumbosacral radiculoplexopathy, 5) after a median of 13\u2009years from radiotherapy for their cancer. Symptoms included focal weakness, paresthesia, cramps, hypoesthesia, amyotrophy, and pain. Patients received bevacizumab at 7.5\u2009mg\/kg\/q2\u2009weeks for a median of six cycles (range, three to nine cycles). Clinical improvement was noted in three cases and clinical stabilization in two. Patients treated within 2\u2009years since symptom onset appeared as most likely to benefit. Enhancement reduction on follow\u2010up MRI was associated with the clinical benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Bevacizumab could be effective in the treatment of RI(R)P, particularly when patients are managed early in their disease. Further prospective clinical trials are warranted to validate these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70587","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T13:51:51Z","timestamp":1779976311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bevacizumab for Radiation\u2010Induced (Radiculo)plexopathy"],"prefix":"10.1111","volume":"33","author":[{"given":"Alberto","family":"Picca","sequence":"first","affiliation":[{"name":"Service de Neuro\u2010Oncologie H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re\u2010Charles Foix, AP\u2010HP, Sorbonne Universit\u00e9  Paris France"},{"name":"Sorbonne Universit\u00e9, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re, ICM  Paris France"},{"name":"OncoNeuroTox Group, Center for Patients With Neurological Complications of Oncologic Treatments Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re et H\u00f4pital Percy  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timoth\u00e9e","family":"Lenglet","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurophysiologie Clinique H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re\u2010Charles Foix, AP\u2010HP, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Vandendries","sequence":"additional","affiliation":[{"name":"Service de Radiologie Fondation Ophtalmologique de Rothschild  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marc","family":"Simon","sequence":"additional","affiliation":[{"name":"Service de Radioth\u00e9rapie H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re\u2010Charles Foix, AP\u2010HP, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Ducloie","sequence":"additional","affiliation":[{"name":"Service de Neurologie CHU de Caen Normandie  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Maisonobe","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurophysiologie Clinique H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re\u2010Charles Foix, AP\u2010HP, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Ricard","sequence":"additional","affiliation":[{"name":"OncoNeuroTox Group, Center for Patients With Neurological Complications of Oncologic Treatments Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re et H\u00f4pital Percy  Paris France"},{"name":"Service de Neurologie H\u00f4pital D'instruction Des Arm\u00e9es Percy, Service de Sant\u00e9 Des Arm\u00e9es  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Psimaras","sequence":"additional","affiliation":[{"name":"Service de Neuro\u2010Oncologie H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re\u2010Charles Foix, AP\u2010HP, Sorbonne Universit\u00e9  Paris France"},{"name":"Sorbonne Universit\u00e9, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re, ICM  Paris France"},{"name":"OncoNeuroTox Group, Center for Patients With Neurological Complications of Oncologic Treatments Groupe Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re et H\u00f4pital Percy  Paris 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