{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:19:28Z","timestamp":1778055568622,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016120","name":"Departamento de Salud, Gobierno de Navarra","doi-asserted-by":"publisher","award":["19\u20102021"],"award-info":[{"award-number":["19\u20102021"]}],"id":[{"id":"10.13039\/501100016120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epidemiological studies carried out on progressive supranuclear palsy (PSP) provide heterogeneous data. Our aim has been to analyze incidence, point prevalence, survival, and time to diagnosis of PSP in Navarre, a northern Spanish region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a population\u2010based observational retrospective study from 2010 to 2022. Data from various sources of health information were reviewed to identify all potential diagnoses of PSP, validated through medical records reviews. Patients were included if they fulfilled the 2017 Movement Disorder Society (MDS) criteria and were classified into the different PSP phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 226 prevalent PSP cases were identified. Age\u2010standardized point prevalence rate at January 1, 2023, was 7.52\/100,000 inhabitants, and age\u2010standardized annual incidence rate (IR) for the period was 2.41\/100,000 person\u2010years. PSP\u2010Richardson syndrome (RS) phenotype showed significantly higher prevalence and incidence rates compared to PSP non\u2010RS phenotypes. Joinpoint regression for overall incidence showed a significant increase until 2018 and thereafter a significant steep decline. Joinpoint regression for prevalence showed a statistically significant annual decline from 2018 onwards. Mortality rate experienced a peak in 2020. Median time to diagnosis was 37\u2009months, and the median survival from clinical symptom onset was 89\u2009months. PSP\u2010RS was associated with reduced time to diagnosis and reduced survival compared to the PSP non\u2010RS phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study represents the first population\u2010based epidemiological study of PSP in Spain and the first with application of the new MDS diagnostic criteria in Europe, providing detailed incidence, prevalence, and mortality data that are in accordance with other European studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70592","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:04:54Z","timestamp":1775135094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology of Progressive Supranuclear Palsy in Navarre, Spain: A Population\u2010Based Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-4100","authenticated-orcid":false,"given":"P.","family":"Arrondo G\u00f3mez","sequence":"first","affiliation":[{"name":"Department of Neuropsychology, Cl\u00ednica Josefina Arregui  Alsasua Navarra Spain"},{"name":"Neuroepigenetics Unit\u2010Navarrabiomed\u2010Universidad P\u00fablica de Navarra (UPNA)\u2010Hospital Universitario de Navarra (HUN) IdiSNA  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1061-2292","authenticated-orcid":false,"given":"E.","family":"Vicente","sequence":"additional","affiliation":[{"name":"Public Health Section, Instituto de Salud P\u00fablica y Laboral de Navarra (ISPLN) IdiSNA  Pamplona Spain"},{"name":"CIBER Epidemiology and Public Health (CIBERESP)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6474-8454","authenticated-orcid":false,"given":"G.","family":"Mart\u00ed\u2010Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario de Navarra (HUN) Navarra Institute for Health Research (IdisNA)  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"S\u00e1nchez Ruiz de Gordoa","sequence":"additional","affiliation":[{"name":"Neuroepigenetics Unit\u2010Navarrabiomed\u2010Universidad P\u00fablica de Navarra (UPNA)\u2010Hospital Universitario de Navarra (HUN) IdiSNA  Pamplona Spain"},{"name":"Department of Neurology, Hospital Universitario de Navarra (HUN) Navarra Institute for Health Research (IdisNA)  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Gast\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario de Navarra (HUN) Navarra Institute for Health Research (IdisNA)  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-7063","authenticated-orcid":false,"given":"P.","family":"Clavero","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Universitario de Navarra (HUN) Navarra Institute for Health Research (IdisNA)  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1691-6908","authenticated-orcid":false,"given":"R.","family":"Valent\u00ed","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cl\u00ednica San Miguel  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-4542","authenticated-orcid":false,"given":"J.","family":"Delfrade","sequence":"additional","affiliation":[{"name":"Public Health Section, Instituto de Salud P\u00fablica y Laboral de Navarra (ISPLN) IdiSNA  Pamplona Spain"},{"name":"CIBER Epidemiology and Public Health (CIBERESP)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9707-4190","authenticated-orcid":false,"given":"M. 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