{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:17:11Z","timestamp":1781187431452,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Progressive supranuclear palsy (PSP) is a rare neurodegenerative tauopathy characterized by early postural instability and vertical gaze palsy. Mitochondrial dysfunctions have been increasingly implicated in the pathogenesis of neurodegenerative disorders, including PSP. We investigated mitochondrial DNA copy number (mtDNA\u2010CN) alterations in the peripheral blood of PSP patients, assessing its potential as a biomarker for disease onset and progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured mtDNA\u2010CN in a cohort of clinically diagnosed PSP patients and age\u2010matched healthy controls using quantitative real\u2010time PCR. We evaluated differences across clinical phenotypes and age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PSP patients exhibited a significant reduction in ND3\u2010CN compared to healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). This depletion remained consistent across age groups, suggesting that mitochondrial impairment in PSP is independent of physiological aging. Although not statistically significant, ND3\u2010CN levels were lower in PSP\u2010parkinsonism (PSP\u2010P) patients compared to those with Richardson's syndrome (PSP\u2010RS). Interestingly, in PSP\u2010RS patients, ND3\u2010CN levels tended to increase with age, potentially reflecting an age\u2010related compensatory mitochondrial response to chronic neuroinflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings support the involvement of mitochondrial dysfunction in PSP pathogenesis, suggesting that peripheral mtDNA\u2010CN may serve as a non\u2010invasive biomarker for disease monitoring. Further studies in larger cohorts are warranted to validate its prognostic potential in different PSP phenotypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70594","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:46:25Z","timestamp":1776426385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Mitochondrial\n                    <scp>DNA<\/scp>\n                    Copy Number in Progressive Supranuclear Palsy Patients: Evidence From a Pilot Study"],"prefix":"10.1111","volume":"33","author":[{"given":"Luigi","family":"Citrigno","sequence":"first","affiliation":[{"name":"Institute for Biomedical Research and Innovation, National Research Council  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Cerantonio","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research and Innovation, National Research Council  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Neuroscience Research Center Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha","family":"Procopio","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Neuroscience Research Center Magna Graecia University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Felicetti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Institute of Neurology, Magna Graecia University  Catanzaro 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