{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T13:05:11Z","timestamp":1779973511658,"version":"3.53.1"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B\u2010002\u2010305\u2010MY2"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B\u2010002\u2010305\u2010MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["114\u2010S0081"],"award-info":[{"award-number":["114\u2010S0081"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated blood pressure (BP) after spontaneous intracerebral hemorrhage (ICH) is associated with poor outcomes, but the prognostic value of prehospital BP, particularly in relation to onset\u2010to\u2010arrival time, remains unclear. We investigated time\u2010dependent associations of prehospital BP, arrival BP, and their early difference with in\u2010hospital outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using a prospectively maintained stroke registry at a tertiary medical center in Taipei, Taiwan (2016\u20132022). Adults (\u2265\u200918\u2009years) with spontaneous ICH transported by emergency medical services within 24\u2009h of symptom onset and with available prehospital BP were included. First prehospital and hospital\u2010arrival BP were analyzed. Outcomes were in\u2010hospital mortality and stroke in evolution (SIE) within 72\u2009h of hospital admission. Patients were stratified by onset\u2010to\u2010arrival time (&lt;\u20093 vs. \u2265\u20093\u2009h). Multivariable logistic regression and restricted cubic splines were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six hundred ninety patients were included (mean age 64.7\u2009years, 63.1% male; 336\u2009&lt;\u20093\u2009h, 354\u2009\u2265\u20093\u2009h). In patients arriving\u2009\u2265\u20093\u2009h, higher prehospital systolic BP, mean arterial pressure, and pulse pressure were independently associated with increased odds of in\u2010hospital mortality, and higher arrival pulse pressure was also associated with mortality. Associations with SIE and early BP differences were weaker and were attenuated in fully adjusted models. Restricted cubic spline showed no nonlinear associations. No significant associations between BP measures and outcomes were observed in patients arriving\u2009&lt;\u20093\u2009h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher prehospital BP was associated with increased in\u2010hospital mortality among patients presenting\u2009\u2265\u20093\u2009h after onset, whereas such associations are not evident within 3\u2009h.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70616","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:33:36Z","timestamp":1778920416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010Dependent Association Between Prehospital Blood Pressure and Outcomes in Acute Spontaneous Intracerebral Hemorrhage"],"prefix":"10.1111","volume":"33","author":[{"given":"Chun\u2010Ju","family":"Lien","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University Hospital Hsin\u2010Chu Branch  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine National Taiwan University  Taipei Taiwan"},{"name":"Health Data Research Center National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Stroke Center and Department of Neurology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Hsuan","family":"Weng","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine National Taiwan University  Taipei Taiwan"},{"name":"Health Data Research Center National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-5973","authenticated-orcid":false,"given":"Sung\u2010Chun","family":"Tang","sequence":"additional","affiliation":[{"name":"Stroke Center and Department of Neurology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Kai","family":"Tsai","sequence":"additional","affiliation":[{"name":"Stroke Center and Department of Neurology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Chih","family":"Ko","sequence":"additional","affiliation":[{"name":"Section of Emergency Medicine, Department of Medicine National Taiwan University Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Kang","family":"Tu","sequence":"additional","affiliation":[{"name":"Health Data Research Center National Taiwan University  Taipei Taiwan"},{"name":"Institute of Health Data Analytics and Statistics National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiann\u2010Shing","family":"Jeng","sequence":"additional","affiliation":[{"name":"Stroke Center and Department of Neurology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3636-6250","authenticated-orcid":false,"given":"Ming\u2010Ju","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Emergency Medicine College of Medicine, National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(04)16405\u20102"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(09)70340\u20100"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.1103"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017985"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.050131"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.531020"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.723874"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010022\u201001169\u20108"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603460"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000407"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102021\u2010327195"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)00806\u20101"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(22)00338\u20106"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00702"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018485"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.038524"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.998"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002747"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000297876.62464.6B"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed\u20102013\u2010203114"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/TME.0000000000000239"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000675"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.037186"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.28.12.2507"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.573543"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.4.891"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2023.04.005"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.1.1"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007704"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000069"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.4.729"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034124"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2016.00864"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19366"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.04.028"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1035061"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096743"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30253\u20109"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2014.16.3.184"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn\u20102016\u2010000047"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.036233"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017701"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010022\u201000866\u20108"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2026.1725724"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873211012133"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.14467"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2021.62.10.911"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.2196\/34386"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70616","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T12:08:50Z","timestamp":1779970130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/ene.70616"],"URL":"https:\/\/doi.org\/10.1111\/ene.70616","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70616"}}