{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T13:05:10Z","timestamp":1779973510080,"version":"3.53.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Functional stroke\u2010like episodes (FSMs) are an increasingly recognised stroke mimic with demographic and clinical characteristics that differ from acute ischaemic strokes (AISs) but have unclear long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We report retrospective data on consecutive patients with FSM who underwent acute perfusion\u2010CT (PCT) admitted to Lausanne University Hospital (2003\u20132017). We compared them to all contemporaneous AISs undergoing PCT from the Acute\u2010STroke\u2010Registry\u2010and\u2010Analysis\u2010of\u2010Lausanne (ASTRAL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010five FSMs and 3201 control\u2010AISs were included. FSM patients were significantly younger (median 43 vs. 73\u2009years, adjusted odds ratio (OR\n                      <jats:sub>adj<\/jats:sub>\n                      ) 0.92), had a higher incidence of psychiatric disorders (OR\n                      <jats:sub>adj<\/jats:sub>\n                      5.33\/17.07), and over half had a prior history of neurological and non\u2010neurological functional disorders. FSM patients more often presented decreased vigilance (OR\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009=\u20099.28) and sensory deficits (OR\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009=\u20093.87), and less visual field defects (OR\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009=\u20090.14) and dysarthria (OR\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009=\u20090.20). FSM patients showed no significant changes on plain\u2010CT and PCT. Acute revascularisation rates were similar in both groups (48% vs. 43%). Follow\u2010up at 3\u2010months revealed significant handicap in 41% of patients, similar to the control group in propensity\u2010score\u2010matched analysis, and lower mortality (0% vs. 20%,\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>adj<\/jats:sub>\n                      0.04). After a median of 9\u2009years follow\u2010up, FSM patients failed to functionally improve further and 55% experienced additional functional neurological events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this single\u2010centre cohort of consecutive FSMs undergoing acute PCT, we identified distinctive demographic and clinical features, normal CT\u2010based neuroimaging, but still a high thrombolysis rate. Long\u2010term observation revealed a high rate of recurrent functional events and persistent disability, suggesting the need for more effective treatment and regular follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70617","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:15:32Z","timestamp":1778051732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Stroke Mimics: Patient Characteristics,\n                    <scp>CT<\/scp>\n                    \u2010Based Multimodal Imaging and Long\u2010Term Outcome in a Comparative Cohort Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-0833","authenticated-orcid":false,"given":"Filipa","family":"Bastos","sequence":"first","affiliation":[{"name":"Stroke Centre, Service of Neurology, Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4429-2714","authenticated-orcid":false,"given":"Davide","family":"Strambo","sequence":"additional","affiliation":[{"name":"Stroke Centre, Service of Neurology, Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8494-5527","authenticated-orcid":false,"given":"Alexander","family":"Salerno","sequence":"additional","affiliation":[{"name":"Stroke Centre, Service of Neurology, Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne  Lausanne 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