{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:17:15Z","timestamp":1783433835491,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the association between optic nerve lesion volume (ONLV) on double inversion recovery (DIR) MRI and other imaging biomarkers of disease burden in multiple sclerosis (MS), including white matter hyperintensities (WMHs), T1\u2010weighted hypointensities, and brain volumetrics. The study explores whether ONLV reflects more severe neurodegenerative MS profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this cross\u2010sectional study, 212 MS patients underwent 3 T MRI, including 3D T1W, FLAIR, and DIR sequences. Optic nerve lesions were segmented on DIR and quantified volumetrically. Patients were categorized by optic nerve involvement: none (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200959), unilateral (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960), bilateral (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993). WMHs were analyzed using AI\u2010based tool. T1W hypointensities and brain volumetrics were extracted using FreeSurfer and AI algorithm applied to 3D T1W and FLAIR images. Multivariate models were adjusted for multiple covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ONLV positively correlated with periventricular (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.365,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), deep (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.165,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), and juxtacortical (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.163,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007) WMHs. Bilateral involvement was associated with higher WMH burden, increased T1W hypointensities (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u200910.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). ONLV was associated with greater white matter atrophy (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u2212107.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016); after adjustment for age, this association was attenuated, while bilateral optic nerve involvement emerged as predictor of gray matter atrophy. Periventricular WMHs also correlated with global cortical and subcortical gray matter loss.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ONLV is associated with greater lesion load and neurodegeneration in MS. Longitudinal studies are needed to confirm prognostic value of ONLV as a candidate biomarker of disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70639","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:45:14Z","timestamp":1780638314000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optic Nerve Lesion Volume, White Matter Hyperintensities, and Brain Volumetrics in Multiple Sclerosis: A Multi\u2010Sequence\n                    <scp>MRI<\/scp>\n                    \u2010Based Analysis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-9819","authenticated-orcid":false,"given":"Adrian","family":"Korbecki","sequence":"first","affiliation":[{"name":"Department of General and Interventional Radiology and Neuroradiology Medical University Hospital  Wroclaw Poland"},{"name":"Hetalox sp. z o.o.  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