{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:16:21Z","timestamp":1783433781080,"version":"3.54.6"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are no clear guidelines for enzyme replacement therapy (ERT) use and obstetric management in pregnant patients with Pompe disease receiving ERT. This study aims to explore outcomes and challenges for these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included French and Dutch patients who became pregnant during ERT. Main outcomes were pregnancy (ERT management, obstetric delivery, neonatal outcomes) and clinical results (6\u2010min walk test [6MWT], forced vital capacity [FVC] in supine and upright positions, infusion associated reactions [IARs]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from 11 patients (median age at pregnancy onset 33\u2009years) with 14 pregnancies were studied. One pregnancy ended in early miscarriage, and 12\/13 live births reached term. Eight pregnancies had an induced birth or planned C\u2010section, 6\/8 due to maternal condition (e.g., increased dyspnea or preference medical team to ensure patient's safety). ERT was continued in eight pregnancies, with three patients receiving an adjusted dose based on their increased weight. ERT was interrupted early in five pregnancies because of trial participation or safety concerns. No IARs were reported during pregnancy or after restart of ERT. Of the patients with clinical data during pregnancy, a (mild) decline was observed in 6\/7 pregnancies for 6MWT, 3\/10 for upright FVC, and 6\/9 for supine FVC. Most patients recovered from their decline during pregnancy within 2\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients who continued ERT during pregnancy, it appeared to be safe, with no documented adverse effects for mother or child. While most patients experienced a mild worsening of clinical condition during pregnancy, the majority recovered well postpartum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70648","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:00:15Z","timestamp":1782396015000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Managing Pompe Disease and Enzyme Replacement Therapy During Pregnancy: Challenges and Considerations"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9160-0202","authenticated-orcid":false,"given":"Maudy T. M.","family":"Theunissen","sequence":"first","affiliation":[{"name":"Department of Neurology, Center for Lysosomal and Metabolic Diseases Erasmus MC University Medical Center  Rotterdam the Netherlands"},{"name":"Department of Pediatrics, Center for Lysosomal and Metabolic Diseases Erasmus MC\u2014Sophia Children's Hospital, University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3418-1116","authenticated-orcid":false,"given":"Zohra","family":"Hayat","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Lysosomal and Metabolic Diseases Erasmus MC University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-1537","authenticated-orcid":false,"given":"Fran\u00e7oise","family":"Bouhour","sequence":"additional","affiliation":[{"name":"Service d'Electroneuromyographie et Pathologies Neuromusculaires, Reference Center for Neuromuscular Diseases PACARARe Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-263X","authenticated-orcid":false,"given":"Johanna M. P.","family":"van den Hout","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center for Lysosomal and Metabolic Diseases Erasmus MC\u2014Sophia Children's Hospital, University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Baptiste","family":"Noury","sequence":"additional","affiliation":[{"name":"Neurophysiology Department Centre Hospitalier Universitaire de Brest, Reference Centre for Neuromuscular Diseases AOC, LBAI INSERM UMR 1227  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmeline","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Department of Neurology Grenoble University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Jouy","sequence":"additional","affiliation":[{"name":"Department of Neurology Nord\/Est\/\u00cele\u2010de\u2010France Neuromuscular Reference Center, FHU PHENIX, AP\u2010HP, Raymond\u2010Poincar\u00e9 Hospital  Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadjib","family":"Taouagh","sequence":"additional","affiliation":[{"name":"Department of Neurology Nord\/Est\/\u00cele\u2010de\u2010France Neuromuscular Reference Center, FHU PHENIX, AP\u2010HP, Raymond\u2010Poincar\u00e9 Hospital  Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-3357","authenticated-orcid":false,"given":"Pieter A.","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Lysosomal and Metabolic Diseases Erasmus MC University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3359-1324","authenticated-orcid":false,"given":"Ans T.","family":"van der Ploeg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center for Lysosomal and Metabolic Diseases Erasmus MC\u2014Sophia Children's Hospital, University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4489-4718","authenticated-orcid":false,"given":"Pascal","family":"Lafor\u00eat","sequence":"additional","affiliation":[{"name":"Department of Neurology Nord\/Est\/\u00cele\u2010de\u2010France Neuromuscular Reference Center, FHU PHENIX, AP\u2010HP, Raymond\u2010Poincar\u00e9 Hospital  Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9161-3301","authenticated-orcid":false,"given":"Nadine A. M. E.","family":"van der Beek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Lysosomal and Metabolic Diseases Erasmus MC University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Pompe Disease","author":"Reuser A. J.","year":"2022"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-88"},{"key":"e_1_2_12_4_1","volume-title":"The Online Metabolic and Molecular Bases of Inherited Disease","author":"Reuser A. J. J.","year":"2019"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909859"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.09.015"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6293-5"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9451-8"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004711"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008441"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2016.01.013"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12272"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-49"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9751-2"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.0552"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00241-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200746"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00331-8"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12236-0"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00518-0"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2024.11.046"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2014.03.010"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2018.08.002"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.09.012"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-019-01089-4"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13055"},{"issue":"9","key":"e_1_2_12_27_1","article-title":"Pregnancy Outcomes in Late Onset Pompe Disease","volume":"10","author":"Goker\u2010Alpan O.","year":"2020","journal-title":"Life (Basel)"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.008615"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-024-03373-w"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.08.006"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.12.024"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13006-025-00775-9"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.26502\/acmcr.96550461"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-13-49"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003847"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.166.4.518"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_12_38_1","unstructured":"National Institutes of Health NCI \u201cCommon Terminology Criteria for Adverse Events Version 5.0\u201d."},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.03.048"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24148"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23854"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437385.88715.4a"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2651"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16383"},{"key":"e_1_2_12_45_1","unstructured":"European Medicines Agency \u201cMyozyme: European Public Assessment Report\u2014Product Information: Annex 1 Summary of Product Characteristics \u201d(2024) https:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/myozyme\u2010epar\u2010product\u2010information_en.pdf."},{"key":"e_1_2_12_46_1","unstructured":"European Medicines Agency \u201cNexviadyme: European Public Assessment Report\u2014Product Information: Annex 1 Summary of Product Characteristics \u201d(2024) https:\/\/ec.europa.eu\/health\/documents\/community\u2010register\/2022\/20220624152828\/anx_152828_en.pdf."},{"key":"e_1_2_12_47_1","unstructured":"European Medicines Agency \u201cPombiliti: European Public Assessment Report \u2014 Product Information: Annex 1 Summary of Product Characteristics \u201d(2024) https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/pombiliti#product\u2010info."},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l869"},{"key":"e_1_2_12_49_1","unstructured":"Network E\u2010P \u201cEuropean Perinatal Health Report 2015\u20132019 \u201d(2022) https:\/\/www.europeristat.com\/publications\/european\u2010perinatal\u2010health\u2010report\u20102015\u20102019\/."},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.05.009"},{"key":"e_1_2_12_51_1","unstructured":"Perined \u201cKerncijfers \u201d(2021) https:\/\/www.perined.nl\/onderwerpen\/publicaties\u2010perined\/kerncijfers\u20102021."},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e25863"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70648","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:36:58Z","timestamp":1783431418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ene.70648"],"URL":"https:\/\/doi.org\/10.1111\/ene.70648","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70648"}}