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This study aimed to identify lesion\u2010derived functional networks associated with impaired mobility, gait, and fall risk in subacute stroke, and to determine whether disruption to these networks is associated with falls during the six\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 94 patients with disabling subacute ischemic stroke from the prospective Baptize cohort, an imaging sub\u2010cohort of the multicenter PHYS\u2010STROKE trial. Principal component (PC) analysis reduced seven mobility\u2010related and four gait\u2010related baseline variables into two composites: PC1\u2010Mobility and PC1\u2010Gait, explaining 56% and 82% of variance, respectively. PC1\u2010Mobility indexed global disability, whereas PC1\u2010Gait reflected spatiotemporal walking capacity. Lesion network mapping (LNM) identified functional networks associated with each domain. Patient\u2010reported falls up to six months post\u2010enrollment were the primary endpoint.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LNM revealed that the mobility\u2010related network predominantly involved cortical regions, whereas the gait\u2010related network was linked to subcortical and infratentorial connectivity. In binary multivariable logistic regression, network similarity scores were not associated with falls; only older age was significant (adjusted OR 1.08, 95% CI 1.02\u20131.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). LNM of fall occurrence identified a cortical network with significant spatial overlap with the mobility\u2010related network (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This exploratory, hypothesis\u2010generating study identified distinct functional networks for post\u2010stroke mobility and gait impairment. Falls may be more closely linked to disruptions in cortical networks supporting voluntary motor control and whole\u2010body coordination than to subcortical gait\u2010modulating structures, potentially informing fall risk stratification and targeted prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifiers: BAPTISe: NCT01954797, PHYS\u2010STROKE: NCT01363856\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70678","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:22:36Z","timestamp":1782303756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Who Falls After a Stroke? Evidence From a Prospective Stroke Cohort"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-313X","authenticated-orcid":false,"given":"Anna","family":"Kufner","sequence":"first","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Zu Berlin Klinik F\u00fcr Neurologie Mit Experimenteller Neurologie  Berlin Germany"},{"name":"Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Zu Berlin Center for Stroke Research Berlin (CSB)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2155-438X","authenticated-orcid":false,"given":"Yunyou","family":"Tang","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin 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