{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:04:46Z","timestamp":1792188286999,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sleep disorders can exacerbate headache burden, yet their prevalence and reversibility in medication\u2010overuse headache (MOH) remain unexplored. We aimed to evaluate sleep disorders and associated factors in MOH patients compared with controls, and to assess outcomes following headache treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective case\u2013control study was conducted at a specialised headache center. Patients aged \u2265\u200918\u2009years with MOH (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009171; mean age 43.3\u2009years; 81.9% female; migraine 64.9%; tension\u2010type headache 35.1%) and age\u2010 and sex\u2010matched headache controls without MOH (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009173; mean age 41.4\u2009years; 74.6% female; migraine 57.8%; tension\u2010type headache 42.2%) underwent semi\u2010structured interviews and standardised assessments including semi\u2010structured interviews, validated questionnaires, headache and sleep calendars and polysomnography when indicated. Follow\u2010up assessments were performed after headache treatment in 87 MOH patients (mean 24.2\u2009months) and 70 controls (mean 26.4\u2009months).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chronic insomnia was more prevalent in MOH than in controls (60.2% vs. 47.4%; OR 1.7, 95% CI 1.1\u20132.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), as was restless legs syndrome (37.4% vs. 22.0%; OR 2.1, 95% CI 1.3\u20133.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Factors associated with chronic insomnia in MOH included nocturnal headache (OR 2.0), nighttime analgesic use (OR 2.5), overweight (OR 2.7), and arterial hypertension (OR 2.6). Following treatment, chronic insomnia decreased to 33.3% and restless legs syndrome to 14.9% (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), paralleling reductions in headache frequency and analgesic use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study to demonstrate high sleep disorder prevalence in MOH and its reversibility following headache treatment. Early screening for sleep disorders in MOH patients is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.70685","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:17:10Z","timestamp":1784200630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sleep Disorders in Medication\u2010Overuse Headache: Prevalence and Associated Factors"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-7113","authenticated-orcid":false,"given":"Elena R.","family":"Lebedeva","sequence":"first","affiliation":[{"name":"Department of Neurology Ural State Medical University  Yekaterinburg Russia"},{"name":"International Headache Center \u2018Europe\u2013Asia\u2019  Yekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6211-0428","authenticated-orcid":false,"given":"Iana A.","family":"Kniazeva","sequence":"additional","affiliation":[{"name":"Department of Neurology Ural State Medical University  Yekaterinburg Russia"},{"name":"International Headache Center \u2018Europe\u2013Asia\u2019  Yekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-5696","authenticated-orcid":false,"given":"Denis V.","family":"Gilev","sequence":"additional","affiliation":[{"name":"Department of Economics Ural Federal University  Yekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6712-2702","authenticated-orcid":false,"given":"Jes","family":"Olesen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center Rigshospitalet\u2010Glostrup, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010020\u201001208\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010018\u20100846\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010023\u201000545\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001037"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.08.018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010020\u201001192\u20105"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2763808"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285617745444"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01282"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_10_12_1","volume-title":"Sleep Medicine Textbook","author":"Bassetti C. L.","year":"2021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(00)00065-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1087\u20100792(98)90050\u20108"},{"key":"e_1_2_10_15_1","first-page":"99","article-title":"A Survey of Multiple Sclerosis, Part 1: Perceived Cognitive Problems and Compensatory Strategy Use","volume":"4","author":"Sullivan M.","year":"1990","journal-title":"Canadian Journal of Rehabilitation"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14268"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012701"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12237"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.87282"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003554"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916\u2010023\u201001160\u2010z"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010017\u20100756\u20108"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.17116\/jnevro202312305289"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008740"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13357"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2007.00858.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2020.16.2.237"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.17116\/jnevro202512506177"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10320"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102982.2007.01303.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2005.05159.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104610.2010.01711.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.2405"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010023\u201001638\u20106"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109384(94)90388\u20103"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2022.11.002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003201"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.11.018"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70463"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ctn8010008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2014.4816"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.17116\/jnevro2025125081127"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.70685","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.70685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:20:38Z","timestamp":1785237638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.70685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/ene.70685"],"URL":"https:\/\/doi.org\/10.1111\/ene.70685","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70685"}}